Chloroform

Drug ingredient

CAS 67-66-3

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$7M

Top sourceGermany 67%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023.

Where It Comes From

Customs basis: HS 290313 · exact

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

Source Countries

Country of origin for US imports, from Census customs data (2024).

DE 67%GermanyIT 25%ItalyIN 6%IndiaTW 1%TaiwanCZ 1%Czech Republic

South Korea

EPA-registered manufacturers (5)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Shin-Etsu Chemical · JP Japan

Occidental Petroleum

Olin

Shintech Louisiana

Tri-Chem Industries

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Chemours

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Honeywell International (123312)

2 FDA-registered drug labelers

Hahnemann Laboratories, INC.

Professional Complementary Health Formulas

Why It Matters

Sectors

Core ChemicalsHealth

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Simple Chlorinated Combination 9315
•Industriox 6011
•Chloroformum
•Toxagent Detox 6035
•Tap Water Detox 6018

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 3 functional roles.

•Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant
•Laboratory chemicals in All Other Basic Organic Chemical ManufacturingProcessing—repackaging
•Solvent in All Other Basic Organic Chemical ManufacturingUse—non-incorporative activities
•Solvent in Pharmaceutical and Medicine ManufacturingUse—non-incorporative activities
•Intermediate in Petrochemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS67-66-3

PubChem CID6212

DTXSIDDTXSID1020306

FormulaCHCl3

Mol. Weight119.37 g/mol

SMILESC(Cl)(Cl)Cl

Data Sources

EPA CompTox (DSSTox) · DTXSID1020306Retrieved 2026-04-06
PubChem · compound 6212Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Chloroform (CAS 67-66-3) https://chemicalindependence.com/chemical/67-66-3/ EPA CompTox (DSSTox): DTXSID1020306. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306 PubChem: 6212. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/6212 EPA Chemical Data Reporting: 67-66-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 67-66-3. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 290313 for CAS 67-66-3. Reporting year: 2024. https://usatrade.census.gov/