Flag of the United StatesAmerican Chemical Independence

Linagliptin

Drug ingredient

CAS 668270-12-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 668270-12-0
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
24 FDA-registered drug labelers
A-S Medication Solutions
Assia Chemical Industries Ltd - Teva Tech Site
Aurobindo Pharma Limited
Bidachem S.p.a.
Biocon Limited
Boehringer Ingelheim Pharma GmbH and Co. KG
Boehringer Ingelheim Pharmaceuticals, Inc.
Boehringer Ingelheim Promeco S.A. de C.V.
Cardinal Health 107, LLC
Cipla Ltd.
CTX Lifesciences Pvt. Ltd.
Dr.Reddy's Laboratories Limited
Granules India Limited
Honour Lab Limited
Macleods Pharmaceuticals Limited
Matrix Pharmacorp Private Limited
Morepen Laboratories Limited
MSN Pharmachem Private Limited
Novadoz Pharmaceuticals LLC
Patheon Pharmaceuticals Inc.
SUN PHARMACEUTICAL INDUSTRIES, INC.
Sunshine Lake Pharma Co., Ltd.
Viyash Life Sciences Private Limited
Zhejiang Huahai Pharmaceutical Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

  • •Jentadueto
  • •Trijardy XR
  • •Glyxambi
  • •Tradjenta
  • •Jentadueto XR
  • •Linagliptin and metformin hydrochloride
  • •linagliptin
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS668270-12-0
PubChem CID10096344
DTXSIDDTXSID201021653
FormulaC25H28N8O2
Mol. Weight472.5 g/mol
SMILESCC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

Data Sources

← Back to Dashboard← Back to Health

Brief citations

Linagliptin (CAS 668270-12-0) https://chemicalindependence.com/chemical/668270-12-0/ PubChem: 10096344. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/10096344 FDA National Drug Code directory: CAS 668270-12-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 668270-12-0. Reporting year: 2024. https://usatrade.census.gov/