1-Adamantanamine, hydrochloride

Drug ingredient

CAS 665-66-7

Companies reported imports and no US production of this drug ingredient to EPA for 2019.

Molecular structure of 665-66-7
1 HCl
US productionZero
Import value, 2024$56M
Import volume2.3M lb
Import dependency100%
Top sourceCzech Republic 24%

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

1-Adamantanamine, hydrochloride · US import value by year
$55M2013$116M2022$56M2024$48M2025

2013: $55M · Peak 2022: $116M · 2024: $56M · 2025: $48M

Where It Comes From

Customs basis: HS 292130 · basket

EPA reports by year
2023
US production Not published · Imports Not published
2019
US production Zero · Imports 2.3M lb

These shares come from HS customs code 292130, which covers 39 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CZ 24%Czech RepublicBE 18%BelgiumDE 17%GermanyCN 16%ChinaCA 4%Canada
EPA-registered importers (1)
Sachem

Why It Matters

Sectors
Core ChemicalsHealth
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Amantadine Hydrochloride
  • •Amantadine HCL
  • •Amantadine
FDA Shortage Status
No Shortage

Vendor Pricing

$0.05/gAaron Chemicals LLC
CountryHong Kong
Pack$25.00 / 500 g
Purity98%
Vendors23 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS665-66-7
PubChem CID64150
DTXSIDDTXSID50874031
FormulaC10H18ClN
Mol. Weight187.71 g/mol
SMILESC1C2CC3CC1CC(C2)(C3)N.Cl

Data Sources

Brief citations

1-Adamantanamine, hydrochloride (CAS 665-66-7) https://chemicalindependence.com/chemical/665-66-7/ EPA CompTox (DSSTox): DTXSID50874031. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID50874031 PubChem: 64150. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/64150 EPA Chemical Data Reporting: 665-66-7. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 665-66-7. Retrieved 2026-06-13. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292130 for CAS 665-66-7. Reporting year: 2024. https://usatrade.census.gov/