Hexamidine diisethionate

Drug ingredient

CAS 659-40-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$240M

Top sourceChina 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292529 · basket

These shares come from HS customs code 292529, which covers 64 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 37%ChinaDE 19%GermanyES 9%SpainIT 8%ItalyID 8%Indonesia

Switzerland
Canada
United Kingdom
Austria
Brazil
Israel
Australia
Hungary
Serbia
Denmark
Malaysia
Poland
Hong Kong
Ukraine
Singapore

2 FDA-registered drug labelers

Guangzhou Zanming Trading Co., Ltd.

Shenzhen Xinxin Yunhai Technology Co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Tuymec Anti-Fungal Shampoo.
•Pharmbanner Anti-Fungal Shampoo.

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.15/gAngene Chemical

CountryChina (registered: Hong Kong)

Pack$574.00 / 500 g

Purity98%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$1.15	100 g	97%
A2B Chem LLC	United States	$1.19	100 g	98%
Aaron Chemicals LLC	Hong Kong	$1.25	100 g	98%
BLD Pharmatech Ltd.	China	$1.36	100 g	97%
Ambeed, Inc.	United States	$1.36	100 g	97%
AA BLOCKS	United States	$1.40	25 g	98%
Apollo Scientific UK	United Kingdom	$1.64	100 g	97%
MedChemExpress MCE	Sweden	$137.94	1 g	98.75%
Otava, Ltd.	Ukraine	$3232.50	40 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS659-40-5

PubChem CID3080571

DTXSIDDTXSID60984372

FormulaC24H38N4O10S2

Mol. Weight606.7 g/mol

SMILESC1=CC(=CC=C1C(=N)N)OCCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O

Data Sources

PubChem · compound 3080571Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Hexamidine diisethionate (CAS 659-40-5) https://chemicalindependence.com/chemical/659-40-5/ PubChem: 3080571. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3080571 FDA National Drug Code directory: CAS 659-40-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292529 for CAS 659-40-5. Reporting year: 2024. https://usatrade.census.gov/