Nintedanib esylate

Drug ingredient

CAS 656247-18-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

14 FDA-registered drug labelers

Apotex Corp.

BDR Lifesciences Private Limited

Biocon Limited

Boehringer Ingelheim Pharma GmbH and Co. KG

Boehringer Ingelheim Pharmaceuticals, Inc.

CHONGQING HUAPONT SHENGCHEM PHARMACEUTICAL CO., LTD.

Edenbridge Pharmaceuticals LLC.

Formosa Laboratories, Inc.

Hetero Labs Limited

Hubei Chengtian Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

MSN Laboratories Private Limited

Sicor de Mexico S.A. de C.V

SUN PHARMACEUTICAL INDUSTRIES, INC.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Nintedanib
•Ofev

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$600.00/gMolnova

CountryChina

Pack$300.00 / 500 mg

Purity99%

Vendors1 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS656247-18-6

PubChem CID135476717

DTXSIDDTXSID40215873

FormulaC33H39N5O7S

Mol. Weight649.8 g/mol

SMILESCCS(=O)(=O)O.CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O

Data Sources

PubChem · compound 135476717Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Nintedanib esylate (CAS 656247-18-6) https://chemicalindependence.com/chemical/656247-18-6/ PubChem: 135476717. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135476717 FDA National Drug Code directory: CAS 656247-18-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293379 for CAS 656247-18-6. Reporting year: 2024. https://usatrade.census.gov/