Isosorbide

CAS 652-67-5

Used in 2 industrial sectors tracked by the EPA.

US production73.7K lb

Import value, 2024$3.5B

Import volume7.3K lb

Import dependency9%

Top sourceIreland 57%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293299 · basket

EPA reports by year

2023: US production 73.7K lb · Imports 7.3K lb
2019: US production 1.2M lb · Imports 80.0K lb

These shares come from HS customs code 293299, which covers 229 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 57%IrelandNL 24%NetherlandsCH 8%SwitzerlandCN 5%ChinaIT 2%Italy

United Kingdom
Japan
Germany
Spain
Israel
Canada
Brazil
Vietnam
Ukraine
New Zealand
Belgium
Mexico
Singapore
Taiwan
South Korea
Sweden
South Africa
Egypt
Indonesia
Lithuania
Finland
Hungary
Czech Republic
Hong Kong
Malaysia
Slovakia
Australia
Russia
Jordan
Latvia
Argentina
Slovenia
Malta
Poland
Denmark
Austria

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Croda

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Roquette America

Why It Matters

Sectors

WaterPlastics & Rubber

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Lubricating agent in Utilities (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS652-67-5

PubChem CID12597

DTXSIDDTXSID5046196

FormulaC6H10O4

Mol. Weight146.14 g/mol

SMILESC1C(C2C(O1)C(CO2)O)O

Data Sources

EPA CompTox (DSSTox) · DTXSID5046196Retrieved 2026-04-06
PubChem · compound 12597Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Water

Brief citations

Isosorbide (CAS 652-67-5) https://chemicalindependence.com/chemical/652-67-5/ EPA CompTox (DSSTox): DTXSID5046196. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5046196 PubChem: 12597. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/12597 EPA Chemical Data Reporting: 652-67-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 652-67-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293299 for CAS 652-67-5. Reporting year: 2024. https://usatrade.census.gov/