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Phentolamine mesylate

Drug ingredient

CAS 65-28-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 65-28-1
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
22 FDA-registered drug labelers
Apicore Pharmaceuticals Private Limited
Apicore Pharmaceuticals Pvt. Ltd.
AX Pharmaceutical Corp
DARMERICA, LLC
Galenova Inc
Hikma Pharmaceuticals USA Inc.
Industriale Chimica s.r.l.
KALCHEM INTERNATIONAL INC
LETCO MEDICAL, LLC
Matrix Pharmacorp Private Limited
NuCare Pharmaceuticals,Inc.
Oyster Point Pharma, Inc.
Pharma Source Direct, Inc.
Precision Dose Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Qingdao Biopeptek Co., Ltd.
QINGDAO TIDA BIOTEK CO.,LTD
RAKSHIT DRUGS PRIVATE LIMITED
Reliable Biopharmaceutical LLC
Septodont, Inc.
Spectrum Laboratory Products, Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Ryzumvi
  • •Phentolamine Mesylate
  • •Oraverse
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$27.28/gAaron Chemicals LLC
CountryHong Kong
Pack$1364.00 / 50 g
Purity98%
Vendors27 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

26 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$27.4250 g98%
A2B Chem LLCUnited States$42.1050 g99%
AA BLOCKSUnited States$55.3450 g99%
Combi-Blocks, Inc.United States$74.005 g98%
CliniSciences GmbHSwitzerland$76.111 g99%
BLD Pharmatech GmbHGermany$82.005 g99%
BLD Pharmatech Ltd.China$82.005 g99%
AK Scientific, Inc.United States$82.005 g98%
BLD Pharmatech Co., LimitedUnited States$90.205 g99%
Ambeed, Inc.United States$90.205 g99%
Sigma-Aldrich (Rush Stock)Germany$180.571 g—
Sigma-AldrichGermany$180.571 g—
MolnovaChina$276.00500 mg99%
TargetMol ChemicalsChina → United States$306.00500 mg99.99%
TargetMol Chemicals EUAustria$335.00200 mg99.99%
AstaTech, IncUnited States$420.001 g98%
MedChemExpress MCESweden$496.10500 mg99.9%
Apexbio Technology LLCUnited States$530.00100 mg98.08%
Cayman EuropeEstonia$672.351 g98%
AK Scientific SpecializedUnited States$940.00100 mg98%
Axon MedchemNetherlands$1200.0050 mg99%
MedKoo Biosciences, IncUnited States$1250.001 g98%
Angene International LimitedUnited States$1316.00250 mg98%
AngeneChina → Hong Kong$4266.6730 mg98%
Key Organics Ltd.United Kingdom$6900.0010 mg98%
TimTec, LLCUnited States$14666.6730 mg90%

Chemical Identity

CAS65-28-1
PubChem CID91430
DTXSIDDTXSID60215315
FormulaC18H23N3O4S
Mol. Weight377.5 g/mol
SMILESCC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.CS(=O)(=O)O

Data Sources

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Brief citations

Phentolamine mesylate (CAS 65-28-1) https://chemicalindependence.com/chemical/65-28-1/ PubChem: 91430. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/91430 FDA National Drug Code directory: CAS 65-28-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 65-28-1. Reporting year: 2024. https://usatrade.census.gov/