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histidine monohydrochloride

Drug ingredient

CAS 645-35-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 645-35-2
1 HCl
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
1 FDA-registered drug labeler
Guna spa

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •GUNA-Matrix
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS645-35-2
PubChem CID66091
DTXSIDDTXSID3020700
FormulaC6H10ClN3O2
Mol. Weight191.61 g/mol
SMILESC1=C(NC=N1)CC(C(=O)O)N.Cl

Data Sources

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Brief citations

histidine monohydrochloride (CAS 645-35-2) https://chemicalindependence.com/chemical/645-35-2/ PubChem: 66091. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/66091 EPA TSCA Inventory: CAS 645-35-2. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 645-35-2. Reporting year: 2024. https://usatrade.census.gov/