Imipenem

Drug ingredient

CAS 64221-86-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$546M

Top sourceItaly 41%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294190 · basket

These shares come from HS customs code 294190, which covers 90 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 41%ItalyCN 24%ChinaDK 9%DenmarkHR 6%CroatiaIN 6%India

United Kingdom
Slovakia
Slovenia
Mexico
Canada
Germany
Belgium
Japan
Switzerland
Netherlands
Czech Republic
Uruguay
South Korea
Hong Kong
Portugal
Australia

4 FDA-registered drug labelers

ACS Dobfar S.p.A

Fresenius Kabi USA, LLC

Merck Sharp & Dohme Corp.

Merck Sharp & Dohme LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Imipenem and Cilastatin
•Primaxin IV

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Imipenem and Cilastatin Injection
Shortage listed since January 8, 2026

See all current drug shortages

Chemical Identity

CAS64221-86-9

PubChem CID104838

DTXSIDDTXSID2023143

FormulaC12H17N3O4S

Mol. Weight299.35 g/mol

SMILESCC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O

Data Sources

PubChem · compound 104838Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Imipenem (CAS 64221-86-9) https://chemicalindependence.com/chemical/64221-86-9/ PubChem: 104838. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/104838 FDA National Drug Code directory: CAS 64221-86-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 64221-86-9. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 294190 for CAS 64221-86-9. Reporting year: 2024. https://usatrade.census.gov/