Demeclocycline hydrochloride

Drug ingredient

CAS 64-73-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$62M

Top sourceChina 82%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294130 · basket

These shares come from HS customs code 294130, which covers 10 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 82%ChinaCH 5%SwitzerlandBG 4%BulgariaTH 4%ThailandIT 2%Italy

Canada
United Kingdom
Israel
India
South Korea

6 FDA-registered drug labelers

American Health Packaging

Amneal Pharmaceuticals LLC

Amneal Pharmaceuticals of New York LLC

CKD Bio Corporation

Epic Pharma, LLC

PuraCap Laboratories LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Demeclocycline Hydrochloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS64-73-3

PubChem CID54686764

DTXSIDDTXSID0045252

FormulaC21H22Cl2N2O8

Mol. Weight501.3 g/mol

SMILESCN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl

Data Sources

PubChem · compound 54686764Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Demeclocycline hydrochloride (CAS 64-73-3) https://chemicalindependence.com/chemical/64-73-3/ PubChem: 54686764. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/54686764 FDA National Drug Code directory: CAS 64-73-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 294130 for CAS 64-73-3. Reporting year: 2024. https://usatrade.census.gov/