morphine sulfate

Drug ingredientActive Shortage

CAS 64-31-3

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$103M

Top sourceAustralia 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293911 · basket

These shares come from HS customs code 293911, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

AU 31%AustraliaGB 27%United KingdomCZ 19%Czech RepublicDE 14%GermanyES 5%Spain

Taiwan
New Zealand

36 FDA-registered drug labelers

Actavis Pharma, Inc.

American Health Packaging

Amneal Pharmaceuticals of New York LLC

Ascend Laboratories, LLC

Bond Pharmacy INC

Bryant Ranch Prepack

Catalent Micron Technologies, Inc.

Civica, Inc.

Cranbury Pharmaceuticals, LLC

Fresenius Kabi USA, LLC

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

International Medication Systems, Limited

LETCO MEDICAL, LLC

Lupin Pharmaceuticals,Inc.

Major Pharmaceuticals

Medisca Inc.

Noramco Coventry LLC

Noramco, LLC

Nortec Development Associates, Inc.

Padagis US LLC

PAI Holdings, LLC dba PAI Pharma

Pharma Source Direct, Inc.

Piramal Critical Care, Inc.

Precision Dose Inc.

Professional Compounding Centers of America

Professional Compounding Centers of America dba PCCA

Redpharm Drug

RedPharm Drug, Inc.

Rhodes Pharmaceuticals L. P.

SpecGx LLC

Spectrum Laboratory Products, Inc.

Sun Pharmaceutical Industries, Inc.

Upsher-Smith Laboratories, LLC

Veranova, L.P.

Winder Laboratories LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 8 drug and cosmetic product listings (FDA).

•Morphine Sulfate
•Duramorph
•Morphine Sulfate Extended Release
•Mitigo
•MS Contin
•Morphine Sulfate ER
•Infumorph 200
•Infumorph 500

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Morphine Sulfate Injection
Shortage listed since October 31, 2017
Manufacturer reports: 2 unavailable, 1 limited, 3 available
to be discontinued
Morphine Sulfate Tablet
Shortage listed since December 22, 2025

See all current drug shortages

Chemical Identity

CAS64-31-3

PubChem CID16051935

DTXSIDDTXSID4023830

FormulaC34H40N2O10S

Mol. Weight668.8 g/mol

SMILESCN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.OS(=O)(=O)O

Data Sources

PubChem · compound 16051935Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

morphine sulfate (CAS 64-31-3) https://chemicalindependence.com/chemical/64-31-3/ PubChem: 16051935. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16051935 FDA National Drug Code directory: CAS 64-31-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 64-31-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293911 for CAS 64-31-3. Reporting year: 2024. https://usatrade.census.gov/