edetate disodium

Drug ingredient

CAS 6381-92-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 6381-92-6 — 2 H₂O · 2 Na⁺

US productionNot reported

Import value, 2024$503M

Top sourceChina 25%

EPA lists this chemical for 2023 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292249 · basket

EPA reports by year

2023: US production Not published · Imports Not published

These shares come from HS customs code 292249, which covers 170 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 25%ChinaIN 17%IndiaSG 13%SingaporeIT 9%ItalyCH 7%Switzerland

Argentina
Poland
Portugal
Lithuania
Ukraine
Finland
Spain
Egypt
Sweden
Austria
Israel
Latvia
Belgium
Ireland
Mexico
Australia
Peru
Czech Republic
Colombia
Hong Kong

Domestic parents -- activity not disclosed (2)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Polyventive

Valudor Products

4 FDA-registered drug labelers

Aloe Vera Korea Co.,Ltd.

Fagron Inc

Laboratium Ofichem BV

Quality Chemicals S.L.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Miracle FootCream Lavender
•Miracle FootCream Lemon

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS6381-92-6

PubChem CID636371

DTXSIDDTXSID5049576

FormulaC10H18N2Na2O10

Mol. Weight372.24 g/mol

SMILESC(CN(CC(=O)O)CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].O.O.[Na+].[Na+]

Data Sources

PubChem · compound 636371Retrieved 2026-04-07
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

edetate disodium (CAS 6381-92-6) https://chemicalindependence.com/chemical/6381-92-6/ PubChem: 636371. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/636371 EPA Chemical Data Reporting: 6381-92-6. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292249 for CAS 6381-92-6. Reporting year: 2024. https://usatrade.census.gov/