Proguanil hydrochloride

Drug ingredient

CAS 637-32-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$240M

Top sourceChina 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292529 · basket

These shares come from HS customs code 292529, which covers 64 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 37%ChinaDE 19%GermanyES 9%SpainIT 8%ItalyID 8%Indonesia

Switzerland
Canada
United Kingdom
Austria
Brazil
Israel
Australia
Hungary
Serbia
Denmark
Malaysia
Poland
Hong Kong
Ukraine
Singapore

15 FDA-registered drug labelers

A-S Medication Solutions

Alivus Life Sciences Limited

BluePoint Laboratories

Bora Pharmaceutical Services Inc.

Divi's Laboratories Limited

GlaxoSmithKline LLC

Glenmark Pharmaceuticals Inc.,USA

Golden State Medical Supply, Inc.

Hetero Drugs Limited

Ipca Laboratories Limited

MYLAN LABORATORIES LIMITED

Mylan Pharmaceuticals Inc.

Prasco Laboratories

Proficient Rx LP

Viyash Life Sciences Private Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Atovaquone and Proguanil Hydrochloride
•Atovaquone and Proguanil Hydrochloride Pediatric
•Malarone
•Atovaquone and Proguanil HCl

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$299.64/gSigma-Aldrich (Rush Stock)

CountryGermany

Pack$299.64 / 1 g

PurityNot recorded

Vendors13 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

12 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich	Germany	$299.64	1 g	—
A2B Chem LLC	United States	$1360.00	100 mg	98.39%
Molnova	China	$1580.00	500 mg	99%
TargetMol Chemicals	China → United States	$1760.00	100 mg	99.03%
AA BLOCKS	United States	$1870.00	100 mg	98.39%
TargetMol Chemicals EU	Austria	$2580.00	50 mg	99.03%
MedChemExpress MCE	Sweden	$2686.20	100 mg	99.21%
Aaron Chemicals LLC	Hong Kong	$3065.00	200 mg	98.39%
Acros Organics	Belgium	$3124.80	25 mg	97%
Angene International Limited	United States	$4780.00	100 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%
MedKoo Biosciences, Inc	United States	$17000.00	50 mg	98%

Chemical Identity

CAS637-32-1

PubChem CID9570076

DTXSIDDTXSID7047776

FormulaC11H17Cl2N5

Mol. Weight290.19 g/mol

SMILESCC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl.Cl

Data Sources

PubChem · compound 9570076Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Proguanil hydrochloride (CAS 637-32-1) https://chemicalindependence.com/chemical/637-32-1/ PubChem: 9570076. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9570076 FDA National Drug Code directory: CAS 637-32-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292529 for CAS 637-32-1. Reporting year: 2024. https://usatrade.census.gov/