Bilirubin

Drug ingredient

CAS 635-65-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

2 FDA-registered drug labelers

BioActive Nutritional, Inc.

Professional Complementary Health Formulas

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Colotox
•Bile Acids Combination 9319

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$32.96/gAA BLOCKS

CountryUnited States

Pack$824.00 / 25 g

Purity97%

Vendors2 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

1 more vendor

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$57.20	5 g	97%

Chemical Identity

CAS635-65-4

PubChem CID5280352

DTXSIDDTXSID8060905

FormulaC33H36N4O6

Mol. Weight584.7 g/mol

SMILESCC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)C=C3C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)C=C4C(=C(C(=O)N4)C=C)C

Data Sources

PubChem · compound 5280352Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Bilirubin (CAS 635-65-4) https://chemicalindependence.com/chemical/635-65-4/ PubChem: 5280352. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5280352 EPA TSCA Inventory: CAS 635-65-4. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293379 for CAS 635-65-4. Reporting year: 2024. https://usatrade.census.gov/