Tripropyl orthoformate

CAS 621-76-1

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$384M

Top sourceMalaysia 21%

At least one company claimed its 2019 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291590 · basket

EPA reports by year

2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291590, which covers 588 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MY 21%MalaysiaDE 13%GermanyNL 13%NetherlandsMX 10%MexicoIT 8%Italy

Singapore
Austria
United Kingdom
Philippines
Canada
Hungary
Turkey
Ukraine
Israel
Denmark
Czech Republic
Slovakia
Norway
Poland
Hong Kong
South Africa
Russia

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Evonik

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant

Vendor Pricing

$1.88/gA2B Chem LLC

CountryUnited States

Pack$47.00 / 25 g

Purity95%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$2.08	25 g	95%
Combi-Blocks, Inc.	United States	$2.10	100 g	95%
BLD Pharmatech GmbH	Germany	$2.35	100 g	95%
BLD Pharmatech Ltd.	China	$2.35	100 g	95%
Ambeed, Inc.	United States	$2.60	25 g	95%
Aaron Chemicals LLC	Hong Kong	$3.02	100 g	95%
Angene Chemical	China → Hong Kong	$3.47	100 g	95%
AstaTech (2 weeks)	United States	$9.10	10 g	95%
BLD Pharmatech Co., Limited	United States	$10.00	1 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	95%

Chemical Identity

CAS621-76-1

PubChem CID69311

DTXSIDDTXSID4044450

FormulaC10H22O3

Mol. Weight190.28 g/mol

SMILESCCCOC(OCCC)OCCC

Data Sources

EPA CompTox (DSSTox) · DTXSID4044450Retrieved 2026-04-06
PubChem · compound 69311Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tripropyl orthoformate (CAS 621-76-1) https://chemicalindependence.com/chemical/621-76-1/ EPA CompTox (DSSTox): DTXSID4044450. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044450 PubChem: 69311. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/69311 EPA Chemical Data Reporting: 621-76-1. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 621-76-1. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291590 for CAS 621-76-1. Reporting year: 2024. https://usatrade.census.gov/