Rifapentine

Drug ingredientActive Shortage

CAS 61379-65-5

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$546M

Top sourceItaly 41%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294190 · basket

These shares come from HS customs code 294190, which covers 90 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 41%ItalyCN 24%ChinaDK 9%DenmarkHR 6%CroatiaIN 6%India

United Kingdom
Slovakia
Slovenia
Mexico
Canada
Germany
Belgium
Japan
Switzerland
Netherlands
Czech Republic
Uruguay
South Korea
Hong Kong
Portugal
Australia

3 FDA-registered drug labelers

Cohance Lifesciences Limited

Interquim, S.A. de C.V.

sanofi-aventis U.S. LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Priftin

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Rifapentine Tablet, Film Coated
Shortage listed since March 25, 2020
Manufacturer reports: 1 available

See all current drug shortages

Chemical Identity

CAS61379-65-5

PubChem CID135403821

DTXSIDDTXSID8041115

FormulaC47H64N4O12

Mol. Weight877 g/mol

SMILESCC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C6CCCC6)C

Data Sources

PubChem · compound 135403821Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Rifapentine (CAS 61379-65-5) https://chemicalindependence.com/chemical/61379-65-5/ PubChem: 135403821. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135403821 FDA National Drug Code directory: CAS 61379-65-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 61379-65-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 294190 for CAS 61379-65-5. Reporting year: 2024. https://usatrade.census.gov/