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Trisodium citrate dihydrate

Drug ingredient

CAS 6132-04-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 6132-04-3
3 Na⁺ · 2 H₂O
US production1.0M lb
Import value, 2024$130M
Import volume42.0K lb
Import dependency4%
Top sourceIsrael 39%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291815 · basket

EPA reports by year
2023
US production 1.0M lb · Imports 42.0K lb
2019
US production Confidential · Imports Zero

These shares come from HS customs code 291815, which covers 34 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IL 39%IsraelIN 14%IndiaDE 13%GermanyCN 10%ChinaIT 6%Italy
EPA-registered manufacturers (2)
Ecolab
Minerals Technologies
EPA-registered importers (1)
Ambyth Chemical
18 FDA-registered drug labelers
60929
Baxter Healthcare Corporation
Citra Labs LLC
CMP Pharma, Inc.
Contract Pharmacal Corp.
CSL Plasma Inc.
CVS PHARMACY,INC.
Fenwal, Inc.
Kobayashi Healthcare International, Inc.
LABORATORIOS GRIFOLS SA
Merck KGaA
Professional Compounding Centers of America
Quality Chemicals S.L.
QUALITY CHOICE (CHAIN DRUG MARKETING ASSOCIATION)
Terumo BCT, Ltd
Terumo Corporation
WALGREENS CO.
WellSpring Pharmaceutical Corporation

Why It Matters

Sectors
HealthConsumer Products
Downstream Uses

Appears in 26 drug and cosmetic product listings (FDA).

  • •CPDA-1
  • •Sodium Citrate 4% w/v Anticoagulant
  • •Anticoagulant Citrate Dextrose A
  • •Nauzene Chewables Ginger Honey
  • •ACD Blood-Pack Units (PL 146 Plastic)
  • •Sodium Citrate Blood-Pack Units, (PL 146 Plastic)
  • •Solucion InterSol
  • •ACD A
Show all 26
  • •Additive Formula 3
  • •Oracit
  • •Nauzene
  • •Emetrol Powder Non-Drowsy
  • •CVS Health Nausea Relief
  • •InterSol
  • •Teruflex Blood with Diversion Blood Sampling Arm 70 mL CPDA-1
  • •teruflex blood bag system with diversion blood sampling arm 70 ml cpda-1
  • •Walgreens Upset Stomach and Nausea Relief
  • •Anticoagulant Sodium Citrate
  • •Anticoagulant Citrate Phosphate Dextrose (CPD) Blood-Pack Units in PL 146 Plastic
  • •Quality Choice Nausea Relief
  • •triCitrasol
  • •Teruflex Blood Anticoagulant Citrate Phosphate Dextrose Adenine (CPDA-1) for Collection of 450mL of Blood
  • •Emetrol Chewables
  • •Emetrol Chewables Mixed Berry
  • •Emetrol Chewables Orange
  • •Sodium Citrate w/v Anticoagulant
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS6132-04-3
PubChem CID71474
DTXSIDDTXSID1049437
FormulaC6H9Na3O9
Mol. Weight294.1 g/mol
SMILESC(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.O.O.[Na+].[Na+].[Na+]

Data Sources

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Brief citations

Trisodium citrate dihydrate (CAS 6132-04-3) https://chemicalindependence.com/chemical/6132-04-3/ EPA CompTox (DSSTox): DTXSID1049437. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1049437 PubChem: 71474. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/71474 EPA Chemical Data Reporting: 6132-04-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 6132-04-3. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291815 for CAS 6132-04-3. Reporting year: 2024. https://usatrade.census.gov/