Tripotassium citrate monohydrate

Drug ingredient

CAS 6100-05-6

EPA’s 2019 records show zero U.S. production for this drug ingredient.

Molecular structure of 6100-05-6 — 3 K⁺ · 1 H₂O

US productionZero

Import value, 2024$130M

Top sourceIsrael 39%

EPA lists this chemical for 2019 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291815 · basket

EPA reports by year

2019: US production Zero · Imports Zero

These shares come from HS customs code 291815, which covers 34 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IL 39%IsraelIN 14%IndiaDE 13%GermanyCN 10%ChinaIT 6%Italy

Brazil
Japan
Netherlands
Australia
Lithuania
United Kingdom
Norway
South Korea
Czech Republic
Lebanon
Ireland
Turkey
Estonia
Mexico
Switzerland

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Cargill, Incorporated

Why It Matters

Sectors

Health

Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

•Potassium Citrate Extended Release
•Potassium Citrate
•Tricitrates
•Kali Citricum
•Urocit-K
•Potassium Citrate and Citric Acid
•TeethWhitening Kit

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Chemical Identity

CAS6100-05-6

PubChem CID2735208

DTXSIDDTXSID8042501

FormulaC6H7K3O8

Mol. Weight324.41 g/mol

SMILESC(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.O.[K+].[K+].[K+]

Data Sources

EPA CompTox (DSSTox) · DTXSID8042501Retrieved 2026-04-06
PubChem · compound 2735208Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
FDA Drug ShortagesRetrieved 2026-06-13
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tripotassium citrate monohydrate (CAS 6100-05-6) https://chemicalindependence.com/chemical/6100-05-6/ EPA CompTox (DSSTox): DTXSID8042501. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID8042501 PubChem: 2735208. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/2735208 EPA Chemical Data Reporting: 6100-05-6. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 6100-05-6. Retrieved 2026-06-13. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 291815 for CAS 6100-05-6. Reporting year: 2024. https://usatrade.census.gov/