Penicillin G

Drug ingredientActive Shortage

CAS 61-33-6

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$78M

Top sourceItaly 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294110 · basket

These shares come from HS customs code 294110, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 33%ItalyCN 31%ChinaBG 22%BulgariaES 8%SpainMX 3%Mexico

Singapore
Israel
Germany
South Korea
Hong Kong
Japan
Switzerland

2 FDA-registered drug labelers

Fersinsa GB, S.A. de C.V

Professional Complementary Health Formulas

Why It Matters

Sectors

Health

Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

•Low Mycosis Nosode 4021
•Toxic Fungi-Mold Nosode 4018
•Mycosis Nosode 4001
•Syphilinum Miasm Drops 2064
•Mycological Immune Stimulator 6010
•Mycotoxin Inhibitor 6020

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Penicillin G Benzathine Injection
Shortage listed since April 26, 2023
Manufacturer reports: 1 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS61-33-6

PubChem CID5904

DTXSIDDTXSID5046934

FormulaC16H18N2O4S

Mol. Weight334.4 g/mol

SMILESCC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C

Data Sources

PubChem · compound 5904Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Penicillin G (CAS 61-33-6) https://chemicalindependence.com/chemical/61-33-6/ PubChem: 5904. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5904 FDA National Drug Code directory: CAS 61-33-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 61-33-6. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 294110 for CAS 61-33-6. Reporting year: 2024. https://usatrade.census.gov/