Papaverine hydrochloride

Drug ingredient

CAS 61-25-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$50M

Top sourceIndia 37%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark

Canada

17 FDA-registered drug labelers

American Regent, Inc.

AX Pharmaceutical Corp

BPI Labs LLC

DARMERICA, LLC

Fagron Inc

Inga Pharmaceuticals

LETCO MEDICAL, LLC

Medisca Inc.

Nexus Pharmaceuticals, LLC

NuCare Pharmaceuticals,Inc.

Oryza Pharmaceuticals Inc.

Pharma Source Direct, Inc.

PROFESSIONAL COMPOUNDING CENTERS OF AMERICA

Professional Compounding Centers of America dba PCCA

RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA

SCL Lifesciences Limited

Willow Birch Pharma, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Papaverine Hydrochloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$4.40/gFluorochem UK

CountryUnited Kingdom

Pack$110.11 / 25 g

Purity95%

Vendors14 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

13 more vendors

Vendor	Country	$/g	Pack	Purity
AK Scientific, Inc.	United States	$4.80	25 g	99%
Combi-Blocks, Inc.	United States	$4.80	25 g	98%
Sigma-Aldrich (Rush Stock)	Germany	$8.57	100 g	—
Sigma-Aldrich	Germany	$8.57	100 g	—
AstaTech, Inc	United States	$19.40	5 g	95%
Interbioscreen	Hong Kong	$34.00	10 g	95%
ChemDiv, Inc.	United States	$75.00	1 g	90%
Labotest KG	Germany	$453.00	1000 mg	90%
Maybridge, Ltd.	United Kingdom	$2414.30	100 mg	90%
Specs	Netherlands	$2534.95	1 g	90%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	90%
Otava, Ltd.	Ukraine	$3232.50	40 mg	95%
AnalytiCon Discovery - a Division of BRAIN Biotech AG	Germany	$73652.70	100 mg	85%

Chemical Identity

CAS61-25-6

PubChem CID6084

DTXSIDDTXSID9025825

FormulaC20H22ClNO4

Mol. Weight375.8 g/mol

SMILESCOC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC.Cl

Data Sources

PubChem · compound 6084Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Papaverine hydrochloride (CAS 61-25-6) https://chemicalindependence.com/chemical/61-25-6/ PubChem: 6084. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6084 EPA TSCA Inventory: CAS 61-25-6. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293919 for CAS 61-25-6. Reporting year: 2024. https://usatrade.census.gov/