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Proline

Drug ingredient

CAS 609-36-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 609-36-9
US productionNot reported
Import value, 2024$1.4B
Top sourceIreland 33%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy
12 FDA-registered drug labelers
Ajinomoto Health & Nutrition North America Inc.
B. Braun Medical Inc.
Baxter Healthcare Company
Baxter Healthcare Corporation
Energique, Inc.
Evonik Rexim S.A.S
Fresenius Kabi USA, LLC
ICU Medical Inc.
Liddell Laboratories, Inc.
Nutritional Specialties, Inc.
Shanghai Plumino Amino Acid Co., Ltd.
Temple Health Nutrition, LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 16 drug and cosmetic product listings (FDA).

  • •Aminosyn-PF
  • •Plenamine
  • •Kabiven
  • •Clinimix
  • •Clinimix E
  • •Clinisol
  • •ProSol
  • •TrophAmine
Show all 16
  • •TH-101
  • •Aminosyn II
  • •Metabatone
  • •Vital Skin Hair Nails
  • •Travasol
  • •Perikabiven
  • •Metab
  • •Premasol - sulfite-free (Amino Acid)
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.09/gAaron Chemicals LLC
CountryHong Kong
Pack$43.00 / 500 g
Purity98%
Vendors30 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

29 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.091 kg98%
A2B Chem LLCUnited States$0.09500 g98%
AA BLOCKSUnited States$0.11500 g98%
ChemsceneUnited States$0.131 kg—
BLD Pharmatech Co., LimitedUnited States$0.141 kg98%
BLD Pharmatech GmbHGermany$0.141 kg98%
BLD Pharmatech Ltd.China$0.141 kg98%
Ambeed, Inc.United States$0.141 kg98%
Fluorochem EUGermany$0.15500 g98%
Fluorochem UKUnited Kingdom$0.15500 g98%
AstaTech, IncUnited States$0.19500 g98%
MedChemExpress MCESweden$0.23500 g98%
AK Scientific SpecializedUnited States$0.251 kg95%
Combi-Blocks, Inc.United States$0.251 kg98%
AK Scientific, Inc.United States$0.351 kg99%
Acrotein ChemBio, Inc.United States$0.42250 g—
Manchester OrganicsUnited Kingdom$0.42250 g—
Angene International LimitedUnited States$0.49100 g98%
Sigma-Aldrich (Rush Stock)Germany$5.1925 g99%
Sigma-AldrichGermany$5.1925 g99%
MolnovaChina$76.00500 mg99%
Labotest KGGermany$217.805000 mg90%
ChemFacesChina$1500.0020 mg98%
Otava, Ltd.Ukraine$1840.00250 mg95%
Princeton BioMolecular Research (SC)United States$4200.0050 mg90%
AngeneChina → Hong Kong$4266.6730 mg98%
Vitas M Chemical LimitedHong Kong$6250.0020 mg90%
Life Chemicals Inc.Ukraine → Canada$9900.0010 mg90%
TimTec, LLC (back-ordered)United States$32000.0015 mg94%

Chemical Identity

CAS609-36-9
PubChem CIDNot recorded
DTXSIDDTXSID9041104
FormulaC5H9NO2
Mol. Weight115.132 g/mol
SMILESOC(=O)C1CCCN1

Data Sources

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Brief citations

Proline (CAS 609-36-9) https://chemicalindependence.com/chemical/609-36-9/ EPA TSCA Inventory: CAS 609-36-9. Retrieved 2026-10-04. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: CAS 609-36-9. Retrieved 2026-10-04. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 609-36-9. Reporting year: 2024. https://usatrade.census.gov/