Selumetinib

Drug ingredient

CAS 606143-52-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.4B

Top sourceIreland 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy

Taiwan
Poland
Canada
Ivory Coast
Greece
Hungary
Indonesia
Latvia
Belgium
Slovakia
Czech Republic
Austria
Netherlands
Finland
Denmark
Croatia
Australia
South Africa
Sweden
Hong Kong
Malta
Singapore
Lithuania
Malaysia
Oman
Serbia

3 FDA-registered drug labelers

AstraZeneca AB

AstraZeneca Pharmaceuticals LP

Patheon Pharmaceuticals Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Koselugo

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$177.70/gAngene Chemical

CountryChina (registered: Hong Kong)

Pack$1777.00 / 10 g

Purity99%

Vendors23 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

22 more vendors

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$194.20	5 g	99%
Combi-Blocks, Inc.	United States	$214.60	5 g	97%
MedKoo Biosciences, Inc	United States	$217.50	20 g	98%
A2B Chem LLC	United States	$229.00	1 g	99%
BLD Pharmatech Ltd.	China	$240.00	5 g	99%
Ambeed, Inc.	United States	$240.00	5 g	99%
AA BLOCKS	United States	$258.00	1 g	99%
TargetMol Chemicals	China → United States	$297.00	1 g	99.9%
BLD Pharmatech Co., Limited	United States	$370.00	1 g	99%
BLD Pharmatech GmbH	Germany	$370.00	1 g	99%
AK Scientific, Inc.	United States	$370.00	1 g	98%
TargetMol Chemicals EU	Austria	$396.00	500 mg	99.9%
Molnova	China	$565.00	200 mg	99%
Apexbio Technology LLC	United States	$594.00	500 mg	98.45%
Angene International Limited	United States	$603.00	1 g	98%
MedChemExpress MCE	Sweden	$643.72	1 g	99.87%
Apollo Scientific UK	United Kingdom	$722.00	500 mg	—
AstaTech, Inc	United States	$908.00	250 mg	98%
Cayman Europe	Estonia	$1725.50	100 mg	95%
ChemFaces	China	$3000.00	20 mg	98%
Axon Medchem	Netherlands	$7680.00	25 mg	99%
Otava, Ltd.	Ukraine	$14233.33	3 mg	97%

Chemical Identity

CAS606143-52-6

PubChem CID10127622

DTXSIDDTXSID3048944

FormulaC17H15BrClFN4O3

Mol. Weight457.7 g/mol

SMILESCN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO

Data Sources

PubChem · compound 10127622Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Selumetinib (CAS 606143-52-6) https://chemicalindependence.com/chemical/606143-52-6/ PubChem: 10127622. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/10127622 FDA National Drug Code directory: CAS 606143-52-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 606143-52-6. Reporting year: 2024. https://usatrade.census.gov/