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cyclosporine

Drug ingredient

CAS 59865-13-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 59865-13-3
US productionNot reported
Import value, 2024$907M
Top sourceIreland 47%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland
38 FDA-registered drug labelers
A-S Medication Solutions
AbbVie Inc.
Allergan, Inc.
American Health Packaging
Amneal Pharmaceuticals NY LLC
Apotex Corp
Catalent Pharma Solutions, LLC
CKD Bio Corporation
Concord Biotech Limited
Curia Italy S.r.l.
Devatis Inc.
Dr. Reddy's Laboratories Inc
Fujian Kerui Pharmaceutical Co., Ltd.
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd
Harrow Eye, LLC
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Joyang Laboratories
KALCHEM INTERNATIONAL INC
KVK-TECH, INC.
LETCO MEDICAL, LLC
Lupin Pharmaceuticals, Inc.
Medisca Inc.
Mylan Pharmaceuticals Inc.
North China Pharmaceutical Huasheng Co. Ltd.
Novartis Pharma Stein AG
Novartis Pharmaceuticals Corporation
Patheon Softgels Inc
PROFESSIONAL COMPOUNDING CENTERS OF AMERICA
Santen Incorporated
Saptalis Pharmaceuticals, LLC
Sterling Pharma Solutions Limited
Sun Pharmaceutical Industries, Inc.
TAPI Czech Industries s.r.o.
Teva Czech Industries s.r.o
Teva Pharmaceuticals USA, Inc.
Teva Pharmaceuticals, Inc.
Upsher-Smith Laboratories, LLC
Zhejiang Ruibang Laboratories

Why It Matters

Sectors
Health
Downstream Uses

Appears in 11 drug and cosmetic product listings (FDA).

  • •Cyclosporine
  • •Restasis
  • •Gengraf
  • •CycloSPORINE, Modfied
  • •Verkazia
  • •Neoral
  • •Restasis MultiDose
  • •Cyclosporine Modified
Show all 11
  • •Cequa
  • •Sandimmune
  • •Vevye
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS59865-13-3
PubChem CID5284373
DTXSIDDTXSID0020365
FormulaC62H111N11O12
Mol. Weight1202.6 g/mol
SMILESCCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Data Sources

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Brief citations

cyclosporine (CAS 59865-13-3) https://chemicalindependence.com/chemical/59865-13-3/ PubChem: 5284373. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5284373 FDA National Drug Code directory: CAS 59865-13-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293379 for CAS 59865-13-3. Reporting year: 2024. https://usatrade.census.gov/