citric acid monohydrate

Drug ingredient

CAS 5949-29-1

Companies reported imports and no US production of this drug ingredient to EPA for 2023.

Molecular structure of 5949-29-1 — 1 H₂O

US productionZero

Import value, 2024$399M

Import volume4.7K lb

Import dependency100%

Top sourceCanada 49%

Production is reported production, not a complete census of factories. Production reporting year: 2023.

citric acid monohydrate · US import value by year

2013: $165M · Peak 2023: $409M · 2024: $399M · 2025: $348M

Where It Comes From

Customs basis: HS 291814 · exact

EPA reports by year

2023: US production Zero · Imports 4.7K lb

Source Countries

Country of origin for US imports, from Census customs data (2024).

CA 49%CanadaMY 35%MalaysiaCO 8%ColombiaCN 2%ChinaTR 2%Turkey

Germany
Taiwan
Italy
Spain
Georgia
Israel
Pakistan
Japan
United Kingdom
Australia
Jordan
Lithuania
Netherlands
Lebanon
Egypt
Chile
Vietnam
Switzerland
South Korea
Serbia
Bahamas

21 FDA-registered drug labelers

Aqua Medica, S.A. de C.V.

Arteriocyte Medical Systems, Inc.

Bayer HealthCare LLC.

Carolina Cannabis Creations LLC

Chartwell Governmental & Specialty RX, LLC

Chartwell RX, LLC

CMP Pharma, Inc.

DNA Labs, Inc.

Earthmed LLC

Energique, Inc.

Evofem, Inc.

Global Life Sciences Solutions USA LLC

Guna spa

Jaymac Pharmaceuticals

Maco Productions

Meridian Bioscience Israel Ltd

Navajo Manufacturing Company Inc.

PAI Holdings, LLC dba PAI Pharma

RB Health Mexico, S.A. de C.V.

Terumo BCT Ltd

Unifirst First Aid Corporation

Why It Matters

Sectors

HealthConsumer Products

Downstream Uses

Appears in 36 drug and cosmetic product listings (FDA).

•Sterile Cord Blood Collection Unit (MSC128D)
•GUNA-FLAM
•Alka-Seltzer Gold
•ACD A
•Additive Formula 3
•Tricitrates
•Oracit
•Medique Medi Seltzer

Show all 36

•Citracid-50
•Lungex II
•D-97
•Phexx
•Pall Sterile Cord Blood Collection Unit
•Soothe Chewable
•Earthmed Soothe Chewable Watermelon
•Earthmed Soothe Chewable Cherry
•Sterile Cord Blood Collection Unit (MSC127D)
•GUNA FLAM Relief
•Anticoagulant Citrate Dextrose A ACD-A
•Sodium Citrate and Citric Acid
•Alka-Seltzer Heartburn
•PaxLyte
•Phexxi
•Sterile CORD Blood Collection UNIT (MSC123D)
•GUNA-CELL
•IDkit HP ONE
•Potassium Citrate and Citric Acid
•Aquacetic-30
•Earthmed Soothe Chewable Strawberry
•Anticoagulant Citrate Dextrose (ACD-A)
•D-99
•Sal De Uvas Picot
•Earthmed Soothe Chewable Orange
•Alka-Seltzer Heartburn Relief Extra Strength
•GUNA-Allergy-PREV
•Alka-Seltzer Heartburn Relief Lemon Lime

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Dispersing agent in Wholesale and Retail TradeNot Known or Reasonably Ascertainable

Chemical Identity

CAS5949-29-1

PubChem CID22230

DTXSIDDTXSID7074668

FormulaC6H10O8

Mol. Weight210.14 g/mol

SMILESC(C(=O)O)C(CC(=O)O)(C(=O)O)O.O

Data Sources

PubChem · compound 22230Retrieved 2026-04-07
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

citric acid monohydrate (CAS 5949-29-1) https://chemicalindependence.com/chemical/5949-29-1/ PubChem: 22230. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/22230 EPA Chemical Data Reporting: 5949-29-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291814 for CAS 5949-29-1. Reporting year: 2024. https://usatrade.census.gov/