Midazolam hydrochloride

Drug ingredientActive Shortage

CAS 59467-96-8

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 59467-96-8 — 1 HCl

US productionNot reported

Import value, 2024$10M

Top sourceItaly 73%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293391 · basket

These shares come from HS customs code 293391, which covers 14 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 73%ItalyIN 21%IndiaIL 4%IsraelFI 1%Finland

China
Switzerland
Germany

24 FDA-registered drug labelers

A-S Medication Solutions

American Health Packaging

Belcher Pharmaceuticals, LLC

Bryant Ranch Prepack

CAMBREX PROFARMACO MILANO SRL

Cardinal Health 107, LLC

Civica, Inc.

COHANCE LIFESCIENCES LIMITED

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

FRESENIUS KABI USA, LLC

Gland Pharma Limited

Henry Schein, Inc.

Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

Jvet Pharmaceuticals LLC

Micro Labs Limited

Padagis US LLC

Precision Dose Inc.

REMEDYREPACK INC.

Sagent Pharmaceuticals

SOMERSET THERAPEUTICS, LLC

Steriscience Specialties Private Limited

Supriya Lifescience Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Midazolam
•Midazolam Hydrochloride
•Midazolam in Sodium Chloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Midazolam Hydrochloride Injection
Shortage listed since April 2, 2020
Manufacturer reports: 1 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS59467-96-8

PubChem CID43032

DTXSIDDTXSID8047846

FormulaC18H14Cl2FN3

Mol. Weight362.2 g/mol

SMILESCC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F.Cl

Data Sources

PubChem · compound 43032Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Midazolam hydrochloride (CAS 59467-96-8) https://chemicalindependence.com/chemical/59467-96-8/ PubChem: 43032. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/43032 FDA National Drug Code directory: CAS 59467-96-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 59467-96-8. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293391 for CAS 59467-96-8. Reporting year: 2024. https://usatrade.census.gov/