Midazolam

Drug ingredientActive Shortage

CAS 59467-70-8

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$10M

Top sourceItaly 73%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293391 · basket

These shares come from HS customs code 293391, which covers 14 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 73%ItalyIN 21%IndiaIL 4%IsraelFI 1%Finland

China
Switzerland
Germany

14 FDA-registered drug labelers

B. Braun Medical Inc.

Cambrex Profarmaco Milano Srl

COHANCE LIFESCIENCES LIMITED

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

Fagron Inc

LETCO MEDICAL, LLC

Pharma Source Direct, Inc.

Professional Compounding Centers of America dba PCCA

Rafa Laboratories, Ltd.

Spectrum Laboratory Products, Inc.

Supriya Lifescience Limited

UCB, Inc.

Wavelength Enterprises LTD

WG Critical Care, LLC.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Midazolam in Sodium Chloride
•Midazolam IN 0.8% Sodium Chloride
•Nayzilam

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Midazolam Hydrochloride Injection
Shortage listed since April 2, 2020
Manufacturer reports: 1 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS59467-70-8

PubChem CID4192

DTXSIDDTXSID5023320

FormulaC18H13ClFN3

Mol. Weight325.8 g/mol

SMILESCC1=NC=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4F

Data Sources

PubChem · compound 4192Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Midazolam (CAS 59467-70-8) https://chemicalindependence.com/chemical/59467-70-8/ PubChem: 4192. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4192 FDA National Drug Code directory: CAS 59467-70-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 59467-70-8. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293391 for CAS 59467-70-8. Reporting year: 2024. https://usatrade.census.gov/