Acyclovir
Drug ingredientCAS 59277-89-3
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%
This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293359 · basket
These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
- Israel
- Bulgaria
- Japan
- Spain
- Sweden
- Canada
- Taiwan
- Finland
- Portugal
- Mexico
- Belgium
- Hungary
- Austria
- Brazil
- Ukraine
- Croatia
- Malta
- South Korea
- South Africa
- Denmark
- Czech Republic
- Malaysia
- Argentina
- Poland
- Cameroon
- Australia
- Hong Kong
- Slovakia
- Latvia
79 FDA-registered drug labelers
A-S Medication Solutions
ACTAVIS PHARMA, INC.
Advagen Pharma Limited
Advanced Rx Pharmacy of Tennessee, LLC
Alembic Pharmaceuticals Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
ANI Pharmaceuticals, Inc.
Apotex Corp.
Asclemed USA, Inc.
ATLANTIC BIOLOGICALS CORP.
Aurobindo Pharma Limited
Avet Pharmaceuticals Inc.
AvPAK
Bausch Health US LLC
Bionpharma Inc.
Bryant Ranch Prepack
Cadila Pharmaceuticals Limited
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
Carlsbad Technology, Inc.
Catalent Micron Technologies, Inc.
Chartwell Governmental & Specialty RX, LLC.
Chartwell RX, LLC
Coupler LLC
Direct_Rx
Fera Pharmaceuticals, LLC
Florida Pharmaceutical Products, LLC
Glenmark Pharmaceuticals Inc., USA
Golden State Medical Supply, Inc.
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Hetero Drugs Limited
HETERO LABS LIMITED
Hubei Yitai Pharmaceutical Co., Ltd
KALCHEM INTERNATIONAL INC
LETCO MEDICAL, LLC
Macleods Pharmaceuticals Limited
Major Pharmaceuticals
Matrix Pharmacorp Private Limited
Medisca Inc.
Modavar Pharmaceuticals LLC
Nivagen Pharmaceuticals, Inc.
Northstar Rx LLC
Northwind Health Company, LLC
Novadoz Pharmaceuticals LLC
NuCare Pharmaceuticals, Inc.
Olon S.p.A.
Padagis Israel Pharmaceuticals Ltd
PD-Rx Pharmaceuticals, Inc.
PharmPak, Inc.
Piramal Pharma Limited
Preferred Pharmaceuticals Inc
PROFESSIONAL COMPOUNDING CENTERS OF AMERICA
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
Quimica Sintetica S.A.
Quinn Pharmaceuticals
RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA
RedPharm Drug
REMEDYREPACK INC.
Signa S.A. de C.V.
Solco Healthcare US, LLC
Spectrum Laboratory Products, Inc.
Sportpharm, Inc. dba Sportpharm
SQUARE PHARMACEUTICALS LIMITED
ST. MARY'S MEDICAL PARK PHARMACY
Sun Pharmaceutical Industries, Inc.
Teva Pharmaceuticals USA, Inc.
Torrent Pharmaceuticals Limited
Union Quimico Farmaceutica SA (UQUIFA)-Sant Celoni
Viona Pharmaceuticals Inc
Westminster Pharmaceuticals, LLC
Xiromed, LLC
YILING PHARMACEUTICAL, INC.
YUNG ZIP CHEMICAL INDUSTRIAL CO., LTD.
Zhejiang Charioteer Pharmaceutical Co, Ltd.
Zhejiang Jiuzhou Pharmaceutical Co., Ltd
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 5 drug and cosmetic product listings (FDA).
- •Acyclovir
- •Acyclovir suspension
- •Avaclyr
- •Zovirax
- •Xerese
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Vendor Pricing
$0.18/gAaron Chemicals LLC
CountryHong Kong
Pack$90.00 / 500 g
Purity98%
Vendors29 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
28 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Angene Chemical | China → Hong Kong | $0.19 | 500 g | 98% |
| Combi-Blocks, Inc. | United States | $0.28 | 1 kg | 98% |
| A2B Chem LLC | United States | $0.32 | 500 g | 98% |
| Chemscene | United States | $0.35 | 500 g | — |
| AA BLOCKS | United States | $0.35 | 1 kg | 98% |
| Fluorochem UK | United Kingdom | $0.40 | 100 g | 95% |
| MedChemExpress MCE | Sweden | $0.44 | 500 g | — |
| Angene International Limited | United States | $1.00 | 500 g | 95% |
| Fluorochem EU | Germany | $1.02 | 25 g | 98% |
| Fulfilled by Molport | Latvia | $50.00 | 100 mg | 98% |
| Interbioscreen | Hong Kong | $64.50 | 10 g | 95% |
| MedKoo Biosciences, Inc | United States | $110.00 | 5 g | 98% |
| Sigma-Aldrich (Rush Stock) | Germany | $125.61 | 1 g | — |
| Sigma-Aldrich | Germany | $125.61 | 1 g | — |
| Labotest KG | Germany | $453.00 | 1000 mg | 90% |
| Apollo Scientific US | United Kingdom | $480.00 | 100 mg | — |
| CliniSciences GmbH | Switzerland | $722.40 | 250 mg | 99% |
| Axon Medchem | Netherlands | $1440.00 | 50 mg | 99% |
| Cayman Europe | Estonia | $1877.82 | 500 mg | 98% |
| Otava, Ltd. (2 weeks) | Ukraine | $2724.00 | 50 mg | 90% |
| ChemDiv, Inc. | United States | $4070.00 | 100 mg | 90% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 98% |
| Acros Organics | Belgium | $4500.00 | 10 mg | 98% |
| Princeton BioMolecular Research (SC) | United States | $5000.00 | 30 mg | 90% |
| Vitas M Chemical Limited | Hong Kong | $5133.33 | 30 mg | 90% |
| Key Organics Ltd. | United Kingdom | $6900.00 | 10 mg | 97% |
| Asinex | Netherlands | $9292.80 | 50 mg | 90% |
| TimTec, LLC | United States | $9333.33 | 30 mg | 95% |
Chemical Identity
CAS59277-89-3
PubChem CID135398513
DTXSIDDTXSID1022556
FormulaC8H11N5O3
Mol. Weight225.2 g/mol
SMILESC1=NC2=C(N1COCCO)N=C(NC2=O)N
Data Sources
- PubChem · compound 135398513Retrieved 2026-04-07
- FDA National Drug Code directoryRetrieved 2026-04-25
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Acyclovir (CAS 59277-89-3) https://chemicalindependence.com/chemical/59277-89-3/ PubChem: 135398513. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135398513 FDA National Drug Code directory: CAS 59277-89-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 59277-89-3. Reporting year: 2024. https://usatrade.census.gov/