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Phenylephrine

Drug ingredient

CAS 59-42-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 59-42-7
US productionNot reported
Import value, 2024$652M
Top sourceSingapore 77%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292250 · basket

These shares come from HS customs code 292250, which covers 76 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 77%SingaporeCN 12%ChinaIT 4%ItalyIN 2%IndiaGB 1%United Kingdom
12 FDA-registered drug labelers
Bayer HealthCare LLC.
Dr. Reddy's Laboratories Inc.
Ebanel Laboratories, Inc
Hengyang Chuangjiujia Trading Co., Ltd.
Hospira, Inc.
JHK DBA American Safety & First Aid
JHK Inc dba American Safety & First Aid
Malladi Drugs & Pharmaceuticals Limited
NeilMed Pharmaceuticals Inc.
Patheon Manufacturing Services LLC
Rayner Surgical Inc.
Walgreen Company

Why It Matters

Sectors
Health
Downstream Uses

Appears in 8 drug and cosmetic product listings (FDA).

  • •Omidria
  • •Liposomal Hemorrhoid Master
  • •Pain and Sinus Reliever
  • •Hemorrhoid Master
  • •Nighttime COLD AND FLU Cherry
  • •Cooling Gel
  • •Pain and Sinus
  • •phenylephrine hydrochloride injection, solution
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS59-42-7
PubChem CID6041
DTXSIDDTXSID9023465
FormulaC9H13NO2
Mol. Weight167.2 g/mol
SMILESCNCC(C1=CC(=CC=C1)O)O

Data Sources

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Brief citations

Phenylephrine (CAS 59-42-7) https://chemicalindependence.com/chemical/59-42-7/ PubChem: 6041. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6041 FDA National Drug Code directory: CAS 59-42-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292250 for CAS 59-42-7. Reporting year: 2024. https://usatrade.census.gov/