Folic acid

Drug ingredient

CAS 59-30-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 59-30-3
US productionNot reported
Import value, 2024$295M
Top sourceChina 56%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293629 · basket

These shares come from HS customs code 293629, which covers 17 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 56%ChinaCH 12%SwitzerlandIN 12%IndiaIT 11%ItalyJP 2%Japan
65 FDA-registered drug labelers
A-S Medication Solutions
Acella Pharmaceuticals, LLC
Advanced Pharmaceutical Services, Inc. Dba Affordable Quality Pharmaceuticals
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals of New York LLC
Aphena Pharma Solutions - Tennessee, LLC
Avion Pharmaceuticals, LLC
Ayurax, LLC
Bestmade Natural Products
Blue Heron Pharmaceuticals, LLC
BonGeo Pharmaceuticals, Inc.
Bryant Ranch Prepack
Cadila Pharmaceuticals Limited
Cardinal Health 107, LLC
CarWin Pharmaceutical Associates, LLC
Chartwell RX, LLC.
Coupler LLC
Deseret Biologicals, Inc.
DIRECT RX
DNA Labs, Inc.
DSM Nutritional Products LLC
Elysium Pharmaceuticals Limited
Exeltis USA, Inc.
Florrax Pharmaceutical
Fresenius Kabi USA, LLC
Fytofontana LLC
Guna spa
Hebei Jiheng Pharmaceutical Co., Ltd.
Hillestad Pharmaceuticals USA
Jaymac Pharmaceuticals
Jaymac Pharmaceuticals, LLC
Leading Pharma, LLC
Major Pharmaceuticals
METHOD PHARMACEUTICALS, LLC
Mission Pharmacal Company
Modavar Pharmaceuticals LLC
NCS HealthCare of KY, LLC dba Vangard Labs
Nnodum Pharmaceuticals
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
Nutritional Specialties, Inc.
Oncora Pharma LLC
Patrin Pharma, Inc.
PD-Rx Pharmaceuticals, Inc.
Preferred Pharmaceuticals Inc.
Professional Complementary Health Formulas
Proficient Rx LP
Pure Source, LLC
PureTek Corporation
QUAGEN PHARMACEUTICALS LLC
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Sandoz Inc
Seton Pharmaceuticals
Solubiomix, LLC
Spectrum Laboratory Products, Inc.
Sri Krishna Pharmaceutical Ltd. Unit I
SUNRISE PHARMACEUTICAL, INC.
U.S. Pharmaceutical Corporation
V2 Pharma LLC
WINDER LABORATORIES, LLC
WOMENS CHOICE PHARMACEUTICALS LLC
XGen Pharmaceuticals DJB, Inc.
Zhejiang Kingland Pharmaceutical Company Limited

Why It Matters

Sectors
Health
Downstream Uses

Appears in 109 drug and cosmetic product listings (FDA).

  • •Folic Acid
  • •Folvitra
  • •Dialyvite
  • •Quflora Pediatric
  • •PNV-DHA
  • •Nestabs Prenatal Multi-vitamin/Mineral Supplement
  • •Integra Plus
  • •Floriva
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.32/gAK Scientific Specialized
CountryUnited States
Pack$320.00 / 1 kg
Purity95%
Vendors2 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS59-30-3
PubChem CID135398658
DTXSIDDTXSID0022519
FormulaC19H19N7O6
Mol. Weight441.4 g/mol
SMILESC1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N

Data Sources

Brief citations

Folic acid (CAS 59-30-3) https://chemicalindependence.com/chemical/59-30-3/ PubChem: 135398658. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135398658 EPA TSCA Inventory: CAS 59-30-3. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293629 for CAS 59-30-3. Reporting year: 2024. https://usatrade.census.gov/