methotrexate
Drug ingredientActive ShortageThis drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.
Where It Comes From
16 FDA-registered drug labelers
Accord Healthcare, Inc.
Antares Pharma, Inc.
AvPAK
Azurity Pharmaceuticals, Inc.
Excella GmbH & Co. KG
Fermion Oy
Hikma Pharmaceuticals USA Inc.
Huzhou Zhanwang Pharmaceutical Co. Ltd
Major Pharmaceuticals
MSN Laboratories Private Limited
Professional Compounding Centers of America dba PCCA
SHORLA ONCOLOGY INC.
Spectrum Laboratory Products, Inc.
Zhejiang Hisun Pharmaceutical Co., Ltd.
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 4 drug and cosmetic product listings (FDA).
- •Methotrexate
- •Otrexup
- •Xatmep
- •Jylamvo
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
Active Shortage
Shortage History
Each row is a separate manufacturer's FDA shortage filing — not a timeline for the drug as a whole. Multiple "current" entries are normal: each manufacturer/NDC files independently. Status reflects the manufacturer's report; reason describes their supply situation (Available, Unavailable, or to be discontinued).
current
Methotrexate Sodium Injection
03/13/2023Limited Availability
current
Methotrexate Sodium Injection
03/13/2023Available
to be discontinued
Methotrexate Injection
08/29/2025current
Methotrexate Sodium Injection
03/13/2023Unavailable
Vendor Pricing
$2.15/gAaron Chemicals LLC
CountryHong Kong
Pack$1073.00 / 500 g
Purity99%
Vendors34 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
33 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Angene Chemical | China → Hong Kong | $2.29 | 500 g | 96% |
| Ambeed, Inc. | United States | $4.32 | 100 g | 99% |
| Chemscene | United States | $4.32 | 100 g | — |
| A2B Chem LLC | United States | $4.80 | 25 g | 99% |
| AA BLOCKS | United States | $5.32 | 25 g | 99% |
| Apollo Scientific UK | United Kingdom | $5.44 | 25 g | — |
| Acrotein ChemBio, Inc. | United States | $5.94 | 100 g | — |
| Fluorochem EU | Germany | $7.26 | 25 g | 97% |
| AstaTech, Inc | United States | $15.40 | 5 g | 97% |
| MedKoo Biosciences, Inc | United States | $29.50 | 100 g | 98% |
| AK Scientific Specialized | United States | $117.20 | 5 g | 95% |
| AK Scientific, Inc. | United States | $156.20 | 5 g | 98% |
| Sigma-Aldrich (Rush Stock) | Germany | $185.80 | 1 g | — |
| Sigma-Aldrich | Germany | $185.80 | 1 g | — |
| TargetMol Chemicals | China → United States | $198.00 | 1 g | 99.91% |
| Angene International Limited | United States | $246.60 | 5 g | 98% |
| Molnova | China | $256.00 | 500 mg | 99% |
| Apexbio Technology LLC | United States | $260.00 | 500 mg | 99.14% |
| MedChemExpress MCE | Sweden | $430.76 | 500 mg | 99.87% |
| Labotest KG | Germany | $453.00 | 1000 mg | 90% |
| TargetMol Chemicals EU | Austria | $540.00 | 100 mg | 99.91% |
| CliniSciences GmbH | Switzerland | $709.50 | 100 mg | 99% |
| Axon Medchem | Netherlands | $1440.00 | 50 mg | 99% |
| ChemFaces | China | $1500.00 | 20 mg | 98% |
| Fulfilled by Molport | Latvia | $2000.00 | 25 mg | 95% |
| Acros Organics | Belgium | $2380.80 | 25 mg | 99% |
| Princeton BioMolecular Research (SC) | United States | $2900.00 | 100 mg | 90% |
| Vitas M Chemical Limited | Hong Kong | $3170.00 | 100 mg | 90% |
| Otava, Ltd. | Ukraine | $3232.50 | 40 mg | 95% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 97% |
| Key Organics Ltd. | United Kingdom | $6900.00 | 10 mg | 97% |
| TimTec, LLC | United States | $30000.00 | 15 mg | 90% |
| TimTec, LLC (back-ordered) | United States | $33333.33 | 15 mg | 94% |
Chemical Identity
CAS59-05-2
PubChem CID126941
DTXSIDDTXSID4020822
FormulaC20H22N8O5
Mol. Weight454.4 g/mol
SMILESCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Data Sources
1269412026-04-07
https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/methotrexate/cids/JSON
Archive: data/sources/pubchem_name/methotrexate.json
CAS 59-05-22026-04-24
https://www.epa.gov/tsca-inventory
Archive: data/sources/tsca/tsca_inventory.csv
CAS 59-05-22026-06-13
https://api.fda.gov/drug/shortages.json
Archive: data/sources/fda/shortages/shortages.json