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Methotrexate

Drug ingredientActive Shortage

CAS 59-05-2

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 59-05-2
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
16 FDA-registered drug labelers
Accord Healthcare, Inc.
Antares Pharma, Inc.
AvPAK
Azurity Pharmaceuticals, Inc.
Excella GmbH & Co. KG
Fermion Oy
Hikma Pharmaceuticals USA Inc.
Huzhou Zhanwang Pharmaceutical Co. Ltd
Major Pharmaceuticals
MSN Laboratories Private Limited
Professional Compounding Centers of America dba PCCA
SHORLA ONCOLOGY INC.
Spectrum Laboratory Products, Inc.
Zhejiang Hisun Pharmaceutical Co., Ltd.
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •Methotrexate
  • •Otrexup
  • •Xatmep
  • •Jylamvo
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Methotrexate Sodium Injection

    Shortage listed since March 13, 2023

    Manufacturer reports: 1 unavailable, 1 limited, 1 available

  • to be discontinued

    Methotrexate Injection

    Shortage listed since August 29, 2025

See all current drug shortages

Vendor Pricing

$2.15/gAaron Chemicals LLC
CountryHong Kong
Pack$1073.00 / 500 g
Purity99%
Vendors34 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

33 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$2.29500 g96%
Ambeed, Inc.United States$4.32100 g99%
ChemsceneUnited States$4.32100 g—
A2B Chem LLCUnited States$4.8025 g99%
AA BLOCKSUnited States$5.3225 g99%
Apollo Scientific UKUnited Kingdom$5.4425 g—
Acrotein ChemBio, Inc.United States$5.94100 g—
Fluorochem EUGermany$7.2625 g97%
AstaTech, IncUnited States$15.405 g97%
MedKoo Biosciences, IncUnited States$29.50100 g98%
AK Scientific SpecializedUnited States$117.205 g95%
AK Scientific, Inc.United States$156.205 g98%
Sigma-Aldrich (Rush Stock)Germany$185.801 g—
Sigma-AldrichGermany$185.801 g—
TargetMol ChemicalsChina → United States$198.001 g99.91%
Angene International LimitedUnited States$246.605 g98%
MolnovaChina$256.00500 mg99%
Apexbio Technology LLCUnited States$260.00500 mg99.14%
MedChemExpress MCESweden$430.76500 mg99.87%
Labotest KGGermany$453.001000 mg90%
TargetMol Chemicals EUAustria$540.00100 mg99.91%
CliniSciences GmbHSwitzerland$709.50100 mg99%
Axon MedchemNetherlands$1440.0050 mg99%
ChemFacesChina$1500.0020 mg98%
Fulfilled by MolportLatvia$2000.0025 mg95%
Acros OrganicsBelgium$2380.8025 mg99%
Princeton BioMolecular Research (SC)United States$2900.00100 mg90%
Vitas M Chemical LimitedHong Kong$3170.00100 mg90%
Otava, Ltd.Ukraine$3232.5040 mg95%
AngeneChina → Hong Kong$4266.6730 mg97%
Key Organics Ltd.United Kingdom$6900.0010 mg97%
TimTec, LLCUnited States$30000.0015 mg90%
TimTec, LLC (back-ordered)United States$33333.3315 mg94%

Chemical Identity

CAS59-05-2
PubChem CID126941
DTXSIDDTXSID4020822
FormulaC20H22N8O5
Mol. Weight454.4 g/mol
SMILESCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Data Sources

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Brief citations

Methotrexate (CAS 59-05-2) https://chemicalindependence.com/chemical/59-05-2/ PubChem: 126941. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/126941 EPA TSCA Inventory: CAS 59-05-2. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 59-05-2. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293359 for CAS 59-05-2. Reporting year: 2024. https://usatrade.census.gov/