Chlorothiazide

Drug ingredient

CAS 58-94-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$2.0B

Top sourceIreland 63%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293590 · basket

These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland

Portugal
Spain
Italy
Austria
Israel
Hungary
Canada
South Korea
Netherlands
Finland
Poland
Indonesia
Ukraine
Mexico
South Africa
Croatia
Greece
Taiwan
Hong Kong

7 FDA-registered drug labelers

Agno Pharma Jiangsu

Cambrex Profarmaco Milano Srl

Chongqing Biocare Pharmaceutical Ltd.

CTX Lifesciences Pvt. Ltd.

MEDISCA Inc.

Salix Pharmaceuticals, Inc

SUN PHARMACEUTICAL INDUSTRIES, INC.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Diuril

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Chlorothiazide Oral Suspension
Shortage listed since February 10, 2026

See all current drug shortages

Vendor Pricing

$0.34/gAK Scientific Specialized

CountryUnited States

Pack$170.00 / 500 g

Purity95%

Vendors14 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

13 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$0.34	500 g	98%
AK Scientific, Inc.	United States	$0.46	500 g	98%
Fulfilled by Molport	Latvia	$3.00	5 g	—
Sigma-Aldrich (Rush Stock)	Germany	$6.18	50 g	—
Sigma-Aldrich	Germany	$6.18	50 g	—
Cayman Europe	Estonia	$22.02	10 g	95%
MedKoo Biosciences, Inc	United States	$90.00	5 g	98%
MedChemExpress MCE	Sweden	$186.34	500 mg	99.63%
Apexbio Technology LLC	United States	$550.00	100 mg	99.88%
Molnova	China	$740.00	50 mg	99%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	90%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	98%
TimTec, LLC	United States	$58000.00	5 mg	90%

Chemical Identity

CAS58-94-6

PubChem CID2720

DTXSIDDTXSID0022800

FormulaC7H6ClN3O4S2

Mol. Weight295.7 g/mol

SMILESC1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2

Data Sources

PubChem · compound 2720Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Chlorothiazide (CAS 58-94-6) https://chemicalindependence.com/chemical/58-94-6/ PubChem: 2720. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2720 EPA TSCA Inventory: CAS 58-94-6. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 58-94-6. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293590 for CAS 58-94-6. Reporting year: 2024. https://usatrade.census.gov/