Hydrochlorothiazide
Drug ingredientActive ShortageCAS 58-93-5
This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.
US productionNot reported
Import value, 2024$2.0B
Top sourceIreland 63%
This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293590 · basket
These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland
- Portugal
- Spain
- Italy
- Austria
- Israel
- Hungary
- Canada
- South Korea
- Netherlands
- Finland
- Poland
- Indonesia
- Ukraine
- Mexico
- South Africa
- Croatia
- Greece
- Taiwan
- Hong Kong
102 FDA-registered drug labelers
A-S Medication Solutions
Accord Healthcare Inc.
Actavis Pharma, Inc.
Advagen Pharma Ltd
Advanced Rx Pharmacy of Tennessee, LLC
Ajanta Pharma USA Inc.
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
Almatica Pharma Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals of New York LLC
Amoli Organics (A Division of Umedica Laboratories Pvt.Ltd.)
ANI Pharmaceuticals, Inc.
Aphena Pharma Solutions - Tennessee, LLC
Apotex Corp.
Ascend Laboratories, LLC
AstraZeneca AB
Aurobindo Pharma Limited
AvKARE
AvPAK
Bausch Health US, LLC
BluePoint Laboratories
Boehringer Ingelheim Pharmaceuticals, Inc.
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cambrex Profarmaco Milano Srl
Changzhou Pharmaceutical Factory
Chartwell RX, LLC
CIPLA USA INC.
Cosette Pharmaceuticals, Inc.
Coupler LLC
CTX Lifesciences Pvt. Ltd.
DIRECT RX
Dr. Reddy's Laboratories Limited
Edenbridge Pharmaceuticals LLC.
Exelan Pharmaceuticals Inc.
GLENMARK PHARMACEUTICALS INC., USA
Golden State Medical Supply, Inc.
Granules Pharmaceuticals Inc.
GSMS, Incorporated
Guna spa
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Hikma Pharmaceuticals USA Inc.
Hisun Pharmaceuticals USA Inc.
Ipca Laboratories Limited
Jubilant Cadista Pharmaceuticals Inc.
Lake Erie Medical DBA Quality Care Products LLC
Leading Pharma, LLC
Legacy Pharmaceutical Packaging, LLC
Lifestar Pharma LLC
Lupin Pharmaceuticals, Inc.
Macleods Pharmaceuticals Limited
Marlex Pharmaceuticals, Inc.
Micro Labs Limited
Mylan Institutional Inc.
Mylan Pharmaceuticals Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
NorthStar Rx LLC
Northwind Health Company, LLC
Novadoz Pharmaceuticals LLC
Novartis Pharmaceuticals Corporation
NuCare Pharmaceuticals, Inc.
Organon LLC
ORGANON PHARMA (UK) LIMITED
Oxford Pharmaceuticals, LLC
Padagis US LLC
Par Health USA, LLC
PD-Rx Pharmaceuticals, Inc.
Prasco Laboratories
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
QPharma Inc
Quality Care Products LLC
Redpharm drug
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Rottendorf Pharma GmbH
Sandoz Inc
Sanofi Winthrop Industire
Sanofi-Aventis U.S. LLC
ScieGen Pharmaceuticals Inc
Siegfried Barbera, SL
Slate Run Pharmaceuticals, LLC
Solco Healthcare LLC
Solco Healthcare U.S., LLC
Spectrum Laboratory Products, Inc.
ST. MARY'S MEDICAL PARK PHARMACY
Strides Pharma Science Limited
Sun Pharmaceutical Industries, Inc.
TAPI Croatia Industries Ltd.
Taro Pharmaceuticals U.S.A., Inc.
Teva Pharmaceuticals USA, Inc.
Unichem Laboratories Limited, India
Unichem Pharmaceuticals (USA), Inc.
Validus Pharmaceuticals LLC
Viona Pharmaceuticals Inc
Westminster Pharmaceuticals, LLC
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 43 drug and cosmetic product listings (FDA).
- •valsartan and hydrochlorothiazide
- •Olmesartan Medoxomil and Hydrochlorothiazide
- •Losartan Potassium and Hydrochlorothiazide
- •Spironolactone and Hydrochlorothiazide
- •Hydrochlorothiazide
- •Lisinopril and Hydrochlorothiazide
- •Bisoprolol Fumarate and Hydrochlorothiazide
- •benazepril hydrochloride and hydrochlorothiazide
Show all 43
- •Micardis HCT
- •Benicar HCT
- •Olmesartan medoxomil Amlodipine and Hydrochlorothiazide
- •Telmisartan and Hydrochlorothiazide
- •Irbesartan AND Hydrochlorothiazide
- •Triamterene and Hydrochlorothiazide
- •Amlodipine, Valsartan, Hydrochlorothiazide
- •Zestoretic
- •Quinapril and Hydrochlorothiazide
- •Candesartan Cilexetil and Hydrochlorothiazide
- •Lisinopril/HCTZ
- •Exforge HCT
- •Captopril AND Hydrochlorothiazide
- •amlodipine,valsartan and hydrochlorothiazide
- •Vaseretic
- •olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide
- •Enalapril Maleate and Hydrochlorothiazide
- •olmesartan medoxomil and amlodipine besylate and hydrochlorothiazide
- •Hyzaar
- •Diovan HCT
- •Lotensin HCT
- •Quinapril HCL and Hydrochlorothiazide
- •Atacand HCT
- •Inzirqo
- •Tribenzor
- •Metoprolol Tartrate and Hydrochlorothiazide
- •Avalide
- •Fosinopril Sodium and Hydrochlorothiazide
- •Quinapril Hydrochloride/Hydrochlorothiazide
- •GUNA-DIUR
- •olmesartan medoxomil-hydrochlorothiazide
- •Quinapril and Hydrochlorothiazide 20/25
- •Quinapril and Hydrochlorothiazide 10/12.5
- •Quinapril and Hydrochlorothiazide 20/12.5
- •Amiloride Hydrochloride and Hydrochlorothiazide
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
Active Shortage
Shortage History
Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.
- to be discontinued
Amlodipine Besylate; Hydrochlorothiazide; Olmesartan Medoxomil Tablet
Shortage listed since June 13, 2025
- Current shortage
Quinapril/Hydrochlorothiazide Tablet
Shortage listed since January 19, 2023
Manufacturer reports: 1 unavailable, 1 available
- to be discontinued
Hydrochlorothiazide; Quinapril Hydrochloride Tablet
Shortage listed since October 1, 2025
- to be discontinued
Hydrochlorothiazide Capsule
Shortage listed since November 19, 2025
Vendor Pricing
$0.55/gA2B Chem LLC
CountryUnited States
Pack$273.00 / 500 g
Purity98%
Vendors28 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
27 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| AA BLOCKS | United States | $0.71 | 500 g | 99% |
| AK Scientific, Inc. | United States | $0.97 | 500 g | 98% |
| Combi-Blocks, Inc. | United States | $1.00 | 100 g | 98% |
| AK Scientific Specialized | United States | $1.03 | 100 g | 95% |
| Biopharma PEG Scientific Inc. | United States | $1.76 | 100 g | 99% |
| Apollo Scientific US | United Kingdom | $1.98 | 100 g | 98% |
| Apexbio Technology LLC | United States | $3.04 | 25 g | 99.64% |
| Sigma-Aldrich (Rush Stock) | Germany | $6.15 | 100 g | — |
| Sigma-Aldrich | Germany | $6.15 | 100 g | — |
| MedChemExpress MCE | Sweden | $11.98 | 10 g | 99.46% |
| Cayman Europe | Estonia | $19.99 | 5 g | 98% |
| MedKoo Biosciences, Inc | United States | $26.00 | 25 g | 98% |
| CliniSciences GmbH | Switzerland | $32.25 | 1 g | 99% |
| Molnova | China | $74.00 | 500 mg | 99% |
| Labotest KG | Germany | $217.80 | 5000 mg | 90% |
| TargetMol Chemicals | China → United States | $580.00 | 50 mg | 99.9% |
| Specs | Netherlands | $1694.00 | 20 mg | 90% |
| Otava, Ltd. | Ukraine | $2280.00 | 50 mg | 95% |
| Maybridge, Ltd. | United Kingdom | $2414.30 | 100 mg | 90% |
| Otava, Ltd. (2 weeks) | Ukraine | $2724.00 | 50 mg | 90% |
| Key Organics Ltd. | United Kingdom | $2740.00 | 50 mg | 95% |
| Princeton BioMolecular Research (SC) | United States | $2900.00 | 100 mg | 90% |
| Vitas M Chemical Limited | Hong Kong | $3170.00 | 100 mg | 90% |
| Life Chemicals Inc. | Ukraine → Canada | $3466.67 | 75 mg | 90% |
| Asinex | Netherlands | $6461.40 | 100 mg | 90% |
| ChemDiv, Inc. | United States | $11300.00 | 10 mg | 90% |
| TimTec, LLC | United States | $16000.00 | 30 mg | 90% |
Chemical Identity
CAS58-93-5
PubChem CID3639
DTXSIDDTXSID2020713
FormulaC7H8ClN3O4S2
Mol. Weight297.7 g/mol
SMILESC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Data Sources
- PubChem · compound 3639Retrieved 2026-04-07
- EPA TSCA InventoryRetrieved 2026-04-24
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Hydrochlorothiazide (CAS 58-93-5) https://chemicalindependence.com/chemical/58-93-5/ PubChem: 3639. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3639 EPA TSCA Inventory: CAS 58-93-5. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 58-93-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293590 for CAS 58-93-5. Reporting year: 2024. https://usatrade.census.gov/