Diphenhydramine

Drug ingredient

CAS 58-73-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$197M

Top sourceChina 36%

EPA lists this chemical as inactive, meaning no company reported making, importing or processing it in the US from 2006 to 2016.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary

Saudi Arabia
Lithuania
Canada
Ukraine
Israel
Singapore
Mexico
Ireland
Netherlands
Malaysia
Slovakia
Denmark
Finland
Latvia
Greece
Austria

12 FDA-registered drug labelers

AARNA USA INC.

Bi-Mart

Catalent Pharma Solutions, LLC

Chain Drug Consortium,LLC

InvaTech Pharma Solutions LLC

Medtech Products Inc.

PUBLIX SUPERMARKETS, INC

Rising Pharma Holdings, Inc.

SAFEWAY

Swati Spentose Private Limited

Tender Corporation d/b/a Adventure Ready Brands

Walgreens

Why It Matters

Sectors

Health

Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

•Percogesic Extra Strength
•Acetaminophen Diphenhydramine HCL
•Dimetane
•Acetaminophen and Diphenhydramine HCL
•Acetaminophen and Diphenhydramine Hydrochloride
•Itch Eraser Gel
•Diphenhydramine HCL 12.5 MG PER 5 ML

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.96/gAaron Chemicals LLC

CountryHong Kong

Pack$196.00 / 100 g

Purity98%

Vendors13 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

12 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$2.11	100 g	95%
A2B Chem LLC	United States	$3.56	25 g	96%
AA BLOCKS	United States	$4.24	25 g	98%
Combi-Blocks, Inc.	United States	$4.75	100 g	96%
AstaTech, Inc	United States	$6.32	25 g	95%
Fulfilled by Molport	Latvia	$9.00	1 g	98%
Angene International Limited	United States	$14.16	25 g	95%
MedKoo Biosciences, Inc	United States	$30.00	25 g	98%
Molnova	China	$100.00	500 mg	99%
TargetMol Chemicals	China → United States	$110.00	500 mg	99.49%
MedChemExpress MCE	Sweden	$251.68	250 mg	99.56%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS58-73-1

PubChem CID3100

DTXSIDDTXSID4022949

FormulaC17H21NO

Mol. Weight255.35 g/mol

SMILESCN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2

Data Sources

PubChem · compound 3100Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Diphenhydramine (CAS 58-73-1) https://chemicalindependence.com/chemical/58-73-1/ PubChem: 3100. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3100 EPA TSCA Inventory: CAS 58-73-1. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292219 for CAS 58-73-1. Reporting year: 2024. https://usatrade.census.gov/