Theophylline

Drug ingredient

CAS 58-55-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6M

Top sourceChina 50%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293959 · basket

These shares come from HS customs code 293959, which covers 9 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 50%ChinaIN 39%IndiaPL 6%PolandIT 4%ItalyDE 1%Germany

United Kingdom

7 FDA-registered drug labelers

Alembic Pharmaceuticals Limited

Kalchem International inc

Leading Pharma, LLC

PAI Holdings, LLC dba PAI Pharma

Shandong Xinhua Pharmaceutical Company Limited

Spectrum Laboratory Products, Inc.

Teva Pharmaceuticals, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Theophylline

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$0.29/gA2B Chem LLC

CountryUnited States

Pack$29.00 / 100 g

Purity97%

Vendors21 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

20 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$0.32	100 g	98%
Aaron Chemicals LLC	Hong Kong	$0.43	500 g	97%
Fluorochem EU	Germany	$0.45	100 g	97%
Fluorochem UK	United Kingdom	$0.46	100 g	97%
Angene Chemical	China → Hong Kong	$0.50	500 g	97%
Angene International Limited	United States	$3.20	25 g	98%
Fulfilled by Molport	Latvia	$5.00	1 g	98%
Apexbio Technology LLC	United States	$10.00	5 g	100%
MedKoo Biosciences, Inc	United States	$22.00	25 g	98%
Molnova	China	$74.00	500 mg	99%
TargetMol Chemicals	China → United States	$82.00	500 mg	99.98%
ChemNorm	China	$300.00	50 mg	98%
Labotest KG	Germany	$453.00	1000 mg	90%
AstaTech (2 weeks)	United States	$990.00	100 mg	95%
ChemFaces	China	$1500.00	20 mg	98%
ChemDiv, Inc.	United States	$4070.00	100 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	97%
Asinex	Netherlands	$8651.50	100 mg	90%
TimTec, LLC	United States	$9333.33	30 mg	90%
AnalytiCon Discovery - a Division of BRAIN Biotech AG	Germany	$89013.91	23 mg	85%

Chemical Identity

CAS58-55-9

PubChem CID2153

DTXSIDDTXSID5021336

FormulaC7H8N4O2

Mol. Weight180.16 g/mol

SMILESCN1C2=C(C(=O)N(C1=O)C)NC=N2

Data Sources

PubChem · compound 2153Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Theophylline (CAS 58-55-9) https://chemicalindependence.com/chemical/58-55-9/ PubChem: 2153. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2153 EPA TSCA Inventory: CAS 58-55-9. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293959 for CAS 58-55-9. Reporting year: 2024. https://usatrade.census.gov/