Promethazine hydrochloride
Drug ingredientActive ShortageCAS 58-33-3
This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.
EPA lists this chemical as inactive, meaning no company reported making, importing or processing it in the US from 2006 to 2016.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293430 · basket
These shares come from HS customs code 293430, which covers 19 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
- Canada
- Switzerland
- United Kingdom
58 FDA-registered drug labelers
Why It Matters
Appears in 12 drug and cosmetic product listings (FDA).
- •Promethazine Hydrochloride
- •Promethegan
- •Promethazine Hydrochloride and Phenylephrine Hydrochloride
- •Promethazine and Phenylephrine HCl, and Codeine Phosphate
- •Promethazine Hydrochloride and Dextromethorphan Hydrobromide
- •Promethazine Hydrochloride and Codeine Phosphate
- •Promethazine
- •Promethazine DM
Show all 12
- •Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral
- •Promethazine Hydrochloride and Dextromethorphan Hydrobromide Oral Solution
- •Phenergan
- •Promethazine HCI
- Current shortage
Promethazine Hydrochloride Injection
Shortage listed since November 21, 2023
Manufacturer reports: 1 unavailable, 1 available
Vendor Pricing
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
21 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Angene Chemical | China → Hong Kong | $1.17 | 500 g | 98% |
| A2B Chem LLC | United States | $1.20 | 100 g | 98% |
| Combi-Blocks, Inc. | United States | $1.20 | 100 g | 98% |
| AA BLOCKS | United States | $1.40 | 100 g | 98% |
| Sigma-Aldrich (Rush Stock) | Germany | $2.68 | 100 g | — |
| Sigma-Aldrich | Germany | $2.68 | 100 g | — |
| Cayman Europe | Estonia | $2.95 | 50 g | 95% |
| AK Scientific, Inc. | United States | $4.64 | 25 g | 98% |
| AstaTech, Inc | United States | $4.92 | 25 g | 95% |
| Angene International Limited | United States | $5.82 | 100 g | 98% |
| MedChemExpress MCE | Sweden | $12.58 | 5 g | 99.85% |
| MedKoo Biosciences, Inc | United States | $15.00 | 50 g | 98% |
| TargetMol Chemicals | China → United States | $29.00 | 1 g | 99.85% |
| Molnova | China | $43.00 | 1 g | 99% |
| Apexbio Technology LLC | United States | $55.00 | 1 g | 98.63% |
| CliniSciences GmbH | Switzerland | $64.50 | 500 mg | 99% |
| Labotest KG | Germany | $453.00 | 1000 mg | 90% |
| AK Scientific Specialized | United States | $680.00 | 100 mg | 99% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 98% |
| Key Organics Ltd. | United Kingdom | $6900.00 | 10 mg | 97% |
| TimTec, LLC (back-ordered) | United States | $32000.00 | 15 mg | 94% |
Chemical Identity
Data Sources
- PubChem · compound 6014Retrieved 2026-04-07
- EPA TSCA InventoryRetrieved 2026-04-24
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Promethazine hydrochloride (CAS 58-33-3) https://chemicalindependence.com/chemical/58-33-3/ PubChem: 6014. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6014 EPA TSCA Inventory: CAS 58-33-3. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 58-33-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293430 for CAS 58-33-3. Reporting year: 2024. https://usatrade.census.gov/