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Testosterone

Drug ingredient

CAS 58-22-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 58-22-0
US productionNot reported
Import value, 2024$154M
Top sourceItaly 60%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293729 · basket

These shares come from HS customs code 293729, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 60%ItalyES 14%SpainCN 11%ChinaDE 6%GermanyAT 2%Austria
52 FDA-registered drug labelers
Acerus Pharmaceuticals Corporation
Actavis Pharma, Inc.
Alembic Pharmaceuticals Inc.
Amneal Pharmaceuticals NY LLC
Apex Energetics Inc.
ASCEND Therapeutics U.S., LLC
Asclemed USA, Inc.
Aspen Oss B.V.
Bayer AG
Bayer de Mexico, S.A. de C.V.
BioActive Nutritional, Inc.
Brichem Sciences Private Limited
Bryant Ranch Prepack
Cipla USA Inc.
COHESION BIOTEC PRIVATE LIMITED
Curia Spain S.A.U.
Deseret Biologicals
Deseret Biologicals, Inc.
DMD Clinical Naturopathy
Dr. Donna Restivo DC
Dr. Reddy's Laboratories Limited
Dr. Reddy's Laboratories, Inc.
Encube Ethicals, Inc.
Endo USA, Inc.
Energique,Inc.
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
Hubei Zhuxi Humanwell Pharmaceutical Co., Ltd.
Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd
Kalchem International inc
LETCO MEDICAL, LLC
Liddell Laboratories, Inc.
Lupin Pharmaceuticals, Inc.
MEDISCA Inc.
Northstar Rx LLC
Padagis Israel Pharmaceuticals Ltd
Pharma Source Direct, Inc.
Pharmacia and Upjohn Company LLC
Prasco Laboratories
Pro Weight Loss Inc.
ProBlen
PROFESSIONAL COMPOUNDING CENTER OF AMERICA
PROFESSIONAL COMPOUNDING CENTERS OF AMERICA
Qinhuangdao Zizhu Pharmaceutical Co., Ltd.
SCH Global Services Private Limited
SHAKTI LIFESCIENCE PRIVATE LIMITED
Spectrum Laboratory Products, Inc.
Strides Pharma Science Limited
Symbiotec Pharmalab Limited
Upsher-Smith Laboratories, LLC
Xiromed, LLC
zhejiang xianju pharmaceutical co., Ltd.
Zoe Processing

Why It Matters

Sectors
Health
Downstream Uses

Appears in 36 drug and cosmetic product listings (FDA).

  • •Testosterone
  • •Testosterone Gel, 1%
  • •Natesto nasal gel
  • •Prostate
  • •Strength F
  • •Male Balance
  • •Young Again
  • •R04 Kidney
Show all 36
  • •AndroGel
  • •Female Stimulant
  • •Immune Forte
  • •R09 Spleen
  • •Dr Dale Wellness NU Fem 1 2 3 All In One Topical Homeopathic
  • •HGH Vitality
  • •High Vitality Tab
  • •Libido
  • •Libidopro
  • •Gynobalance
  • •Vital Male Sexual Energy
  • •Strength M
  • •G03 TEST-MET
  • •Hormone Harmony
  • •HP Axis
  • •Natural Testosterone
  • •High Vitality
  • •Vogelxo
  • •TestoPRO
  • •Hormone Balance
  • •Male Stimulant
  • •Hormone Combination
  • •G12 Hepar MET
  • •Testim
  • •Testopel
  • •Viril
  • •Androbalance
  • •Immune PLUS Formula
FDA Shortage Status
No Shortage
Shortage History
  • to be discontinued

    Testosterone Gel; Gel, Metered

    Shortage listed since June 16, 2025

See all current drug shortages

Chemical Identity

CAS58-22-0
PubChem CID6013
DTXSIDDTXSID8022371
FormulaC19H28O2
Mol. Weight288.4 g/mol
SMILESCC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C

Data Sources

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Brief citations

Testosterone (CAS 58-22-0) https://chemicalindependence.com/chemical/58-22-0/ PubChem: 6013. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6013 EPA TSCA Inventory: CAS 58-22-0. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 58-22-0. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293729 for CAS 58-22-0. Reporting year: 2024. https://usatrade.census.gov/