Pyrimethamine

Drug ingredient

CAS 58-14-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 58-14-0
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
16 FDA-registered drug labelers
ANUH PHARMA LIMITED
Aurobindo Pharma Limited
DARMERICA, LLC
DR.REDDYS LABORATORIES INC
Fukuzyu Pharmaceutical Co., Ltd
HIKAL LIMITED
Interquim, S.A. de C.V.
Ipca Laboratories Limited
Kalchem International inc
NorthStar Rx LLC
OAKRUM PHARMA, LLC
Professional Compounding Centers of America
R.L.Fine Chem Private Limited
Teva Pharmaceuticals, Inc.
TILDE Sciences LLC
Vyera Pharmaceuticals LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Pyrimethamine
  • •Daraprim
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.29/gAaron Chemicals LLC
CountryHong Kong
Pack$146.00 / 500 g
Purity98%
Vendors24 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS58-14-0
PubChem CID4993
DTXSIDDTXSID9021217
FormulaC12H13ClN4
Mol. Weight248.71 g/mol
SMILESCCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl

Data Sources

Brief citations

Pyrimethamine (CAS 58-14-0) https://chemicalindependence.com/chemical/58-14-0/ PubChem: 4993. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4993 FDA National Drug Code directory: CAS 58-14-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 58-14-0. Reporting year: 2024. https://usatrade.census.gov/