Caffeine
Drug ingredientCAS 58-08-2
Companies reported imports and no US production of this drug ingredient to EPA for 2019.
US productionZero
Import value, 2024$106M
Import volume219.6K lb
Import dependency100%
Top sourceChina 46%
Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Caffeine · US import value by year
2013: $59M · Peak 2022: $142M · 2024: $106M · 2025: $132M
Where It Comes From
Customs basis: HS 293930 · narrow
EPA reports by year
- 2019
- US production Zero · Imports 219.6K lb
These shares come from HS customs code 293930, which covers 2 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
CN 46%ChinaDE 28%GermanyIN 14%IndiaIT 7%ItalyGB 2%United Kingdom
- Austria
- Japan
- Israel
- Belgium
- Sweden
- Spain
- Indonesia
- Switzerland
EPA-registered importers (2)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Brenntag
Pht International
194 FDA-registered drug labelers
A-S Medication Solutions
AAA PHARMACEUTICAL, INC.
Acme United Corporation
Actavis Pharma, Inc.
Advanced Rx LLC
Advanced Rx of Tennessee, LLC
Advanced Rx Pharmacy of Tennessee, LLC
Aero Healthcare
Allegiant Health
Amazon.com Services LLC
American Health Packaging
American Regent, Inc.
American Sales Company
Amerisource Bergen
Amneal Pharmaceuticals of New York, LLC
ARMY AND AIR FORCE EXCHANGE SERVICE
Asclemed USA, Inc.
Atland Pharmaceuticals, LLC
Aurobindo Pharma Limited
Aurohealth LLC
Aurolife Pharma, LLC
AvKARE
AvPAK
Bayer HealthCare LLC
Beijing JUNGE Technology Co., Ltd.
Bell Pharmaceuticals, Inc
Belmora LLC
Bestmade Natural Products
BETTER LIVING BRANDS, LLC
Bi-Mart
Bioventure Healthcare - FZE
Breckenridge Pharmaceutical, Inc.
Bryant Ranch Prepack
Cabinet Health P.B.C.
Cardinal Health 107, LLC
Cardinal Health 110, LLC. DBA Leader
Carolina Cannabis Creations LLC
Catalent Micron Technologies, Inc.
Chain Drug Consortium
Chain Drug Marketing Association
CHAIN DRUG MARKETING ASSOCIATION INC
Chartwell RX, LLC
Cintas Corporation
Cintex Services, LLC
Command Brands, LLC
Contract Pharmacal Corp.
Cosette Pharmaceuticals, Inc.
CVS Pharmacy
CVS PHARMACY, INC
DEFT CHEMICALS PRIVATE LIMITED
Deseret Biologicals, Inc.
Direct_Rx
DISCOUNT DRUG MART
Dolgencorp Inc
Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)
DOLGENCORP, LLC
Dollar General
DONGWHA PHARM. CO. LTD.
Dr. Reddy's Labratories Inc.
DSE Healthcare Solutions, LLC
Earthmed LLC
Elysium Pharmaceutical Ltd
Energetix Corporation
EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC)
FAMILY DOLLAR
Family Dollar (FAMILY WELLNESS)
Family Dollar Services Inc
Farmacias De Similares TX LLC
Focus Consumer Healthcare, LLC
FSA STORE INC.
Galt Pharmaceuticals, LLC
Geiss, Destin & Dunn Inc.
Genomma Lab USA
Genus Lifesciences Inc.
Geri-Care Pharmaceutical Corp
GM Pharmaceuticals, INC
Golden State Medical Supply, Inc.
Granules India Ltd
Granules Pharmaceuticals Inc.
Green Earth Health Inc.
Grocery Outlet
Guangdong Joyan Biological Technology Co.,Ltd
Guangdong Junhui Biotechnology Co., LTD
Guangzhou Ariel Biotech Co., Ltd.
Guangzhou Binsi Clothing Co.,Ltd.
Guangzhou Yapeng Refinement Chemical Co., Ltd.
Guna spa
H E B
Hahnemann Laboratories, INC.
Haleon US Holdings LLC
HARRIS TEETER
HART Health
Healthlife of USA
Hi-Tech Nutraceuticals, LLC
Hikma Pharmaceuticals USA Inc.
Insight Pharmaceuticals LLC
JC World Bell Wholesale Co., Inc
JHK Inc dba American Safety & First Aid
Jones Healthcare Group - Packaging Services, Inc
Kobayashi Healthcare International, Inc
KROGER COMPANY
KVK-Tech, Inc.
L. Perrigo Company
L.N.K. International, Inc.
Laboratorios Sanfer, S.A. de C.V.
Lannett Company, Inc.
LEADER/ Cardinal Health 110, Inc.
LETCO MEDICAL, LLC
LGM PHARMA SOLUTIONS, LLC
Lil Drug Store Products, Inc
Lydia Co., Ltd.
Magno-Humphries, Inc.
Major Pharmaceuticals
Marc Glassman, Inc.
Mayne Pharma
Medisca Inc.
Medline Industries, LP
Medtech Products Inc.
Meijer Distribution Inc
Mikart, LLC
NaturalCare
Navajo Manufacturing Company Inc.
Newton Laboratories, Inc.
NORTHSTAR RX LLC
NuCare Pharmaceuticals, Inc.
NUVICARE LLC
O Positiv, Inc.
OPMX LLC
P & L Development, LLC
Patheon Softgels Inc.
Pharmadel LLC
Pioneer Life Sciences, LLC
Poly Pharmaceuticals, Inc.
Preferred Pharmaceuticals Inc.
Prodose, Inc.
Professional Complementary Health Formulas
Proficient Rx LP
PUBLIX SUPER MARKETS INC
QUAGEN PHARMACEUTICALS LLC
R J General Corporation
Rally Labs LLC
Raritan Pharmaceuticals Inc.
Redpharm Drug
Reese Pharmaceutical Co
REMEDYREPACK INC.
RETAIL BUSINESS SERVICES , LLC.
Rising Pharma Holdings, Inc.
Rite Aid Corporation
Rugby Laboratories
Safeway
Safeway, Inc
Safrel Pharmaceuticals, LLC.
Salado Sales, Inc.
Sandoz Inc
Select Consumer Group
Seton Pharmaceuticals LLC
Shandong Xinhua Pharmaceutical Company Limited
Shield Pharmaceuticals Corp
Siegfried PharmaChemikalien Minden GmbH
Softgel Healthcare Pvt Ltd
SOLCO HEALTHCARE US, LLC
Sportpharm LLC
ST. MARY'S MEDICAL PARK PHARMACY
Strategic Sourcing Services LLC
Strides Pharma Science Limited
Strive Pharmaceuticals Inc.
SUNRISE PHARMACEUTICAL, INC
TARGET
TARGET CORPORATION
Taro Pharmaceuticals U.S.A., Inc.
TCB USA Corporation
The Kroger Co.
Thompson Safety
TIME CAP LABS
TIME CAP LABS INC
TOP CARE (Topco Associates LLC)
TopCo Associates, LLC
Trifluent Pharma, LLC
Unifirst First Aid Corporation
United Natural Foods, Inc. dba UNFI
VALU MERCHANDISERS COMPANY
Value Merch
VESPYR BRANDS, INC.
VIVUNT PHARMA LLC
WAL-MART STORES INC
WALGREEN CO
Walgreen Company
WALGREENS
WALGREENS CO.
Walmart
WALMART INC.
Westminster Pharmaceuticals, LLC
Wildman Business Group
WinCo Foods, LLC
Why It Matters
Sectors
Core ChemicalsHealth
Downstream Uses
Appears in 214 drug and cosmetic product listings (FDA).
- •Pamprin Max Menstrual Pain Relief
- •Stay Awake
- •Butal/APAP/Caff
- •Topcare Stay Awake Maximum Strength
- •Excedrin Extra Strength Pain Reliever
- •Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
- •Uplift Chewable
- •Earthmed Uplift Chewable Cherry
Show all 214
- •Bestmade Natural Products BM47
- •Menstrual Pain Relief Complete
- •AOAO Retinol Anti-aging Box Set
- •Stay Awake Maximum Strength
- •good sense migraine formula
- •Cafiaspirina Rapid Headache Relief
- •Extra Strength Headache Relief
- •Extra Strenght Headache Relief
- •Headache Relief Extra Strength
- •Butalbital, Acetaminophen AND Caffeine
- •Cand Plus
- •Extra PAIN Relief
- •Midol Complete
- •BackAid
- •Migraine Relief
- •Allergies
- •Acetaminophen, Aspirin and Caffeine
- •Caffeinum
- •Alka-Seltzer Hangover Relief
- •Aller-Chord F
- •Headache Relief
- •Butalbital, Acetaminophen, Caffeine
- •Buscapina
- •Caffeine
- •leader migraine relief
- •Menstrual Complete
- •basic care migraine relief
- •Butalbital, aspirin, and caffeine
- •PAIN Relief Caffeine AND Snake Venom
- •5% Minoxidil Hair Growth Serum
- •Excedrin Migraine
- •JET Alert Regular Strength
- •Acetaminophen , Caffeine and pyrilamine maleate
- •migraine formula
- •Menstrual Relief
- •Medique Pain Off
- •Ascomp with Codeine
- •Diurex Water Pills XPL
- •Fioricet
- •Headache Formula Extra Strength
- •Caffeine Mix 1003
- •Best Choice Pain Relief Powder
- •Excedrin Extra Strength, Travel Basix
- •Excedrin Extra Strength, CVP Health
- •Midol
- •Awake Maximum Strength
- •Kortribion Pain Reliever
- •Acetaminophen, Aspirin, Caffeine
- •Acetaminophen 250mg Aspirin 250mg Caffeine 65mg
- •foster and thrive migraine relief
- •Tension Headache Relief
- •Walmart Pain Relief Powder
- •Extra Strength PAIN Reliever
- •Earthmed Uplift Chewable Orange
- •Bestmade Natural Products BM249
- •Anti-wrinkle eye cream
- •YVES Conopeptide Luxury Tighten Creme EYE MASK
- •Multi-Symptom Menstrual Relief
- •Tension Headache Aspirin-Free
- •ergotamine tartrate and caffeine
- •Back and Body
- •Medi First Plus Pain Ache
- •Back and Body Extra Strength
- •Stanback
- •Goodys Extra Strength Headache Mixed Fruit Blast
- •Menstrual Complete Maximum Strength
- •Extra Strength Headache, Lil Drug Store
- •Excedrin Migraine, Travel Basix
- •Back and Body Pain Relief
- •Alertness Aid
- •Dolodol
- •Vivarin
- •TopCare Extra Strength Headache Relief
- •Excedrin Extra Strength Headache
- •Excedrin Extra Strength Geltabs
- •Reese Headache Powders
- •Menstrual Relief Extra Strength
- •Panadol Extra
- •Xpect Pain Away Extra Strength
- •Diurex Water Pills
- •Fioricet with Codeine
- •BC
- •Headache Relief, Extra Strength 24/7 Life by 7-Eleven
- •Excedrin Extra Strength
- •Thompson XS Pain Ache
- •Gemma Cut the Cramp
- •Excedrin Tension Headache
- •Pain Terminator Extra Strength Pain Relief
- •5%Minoxidil Hair Growth Sprays Serum
- •ANTI-Aging EYE MASK
- •Noavia Retinol Moisturizer
- •YVES ICED Americano Energy MASK
- •JET Alert Double Strength
- •good neighbor pharmacy migraine relief
- •Topcare Migraine Relief
- •Green Guard Extra Strength Pain Relief
- •Alert
- •Dolex Fem
- •Goodys MAX
- •BC Arthritis
- •Trezix
- •Anacin
- •Isopathic Phenolic Rings
- •Extra Strength Headache
- •Menstrual Relief Maximum Strength
- •SED-MAX
- •Artrifin 24 Caplets
- •Doloneuro-Tropas
- •Tension Headache
- •Orphenadrine Citrate, Aspirin and Caffeine
- •Excedrin Migraine Relief
- •ValuMeds Extra Strength Headache Relief
- •Pain Reliever Extra Strength
- •Exaprin Plus
- •dg health migraine relief
- •Dollar General Headache Powders
- •Goodys Cool Orange Headache
- •Midol Complete Gelcaps
- •Extra Strength Headache, Circle K
- •Acetaminophen 500mg Caffeine 60mg Pyrilamine maleate 15mg
- •Cafizetamol Forte
- •Amazon Basic CARE Migraine Relief
- •Novominsyrup
- •Cafergot
- •Tension Headache Pain Relieving Aid
- •Notts - Tension Headache
- •5% Minoxidil Hair Growth Foam
- •5% Minoxidil Topical Aerosol(For Men)
- •Feelshion 6% Caffeine 1% Retinol Eye Cream
- •Dr Simi Extra Strength Acetaminophen 250 mg, Aspirin 250 mg, and Caffeine 65 mg
- •vanquish
- •Alert Aid
- •BioElectro Extra Strength Headache Relief
- •Alert Alertness Aid
- •Norgesic Forte
- •Pancold A
- •Dolex Forte
- •dg health headache relief
- •Publix Super Markets INC
- •BC Cherry
- •Goodys Extra Strength
- •Goodys Hangover
- •Goodys Mental Alert
- •Butalbital, Aspirin, Caffeine AND Codeine Phosphate
- •Bayer Rapid Relief
- •Alka-Seltzer Extra Strength Pain Relief
- •Quality Choice Pain Relief Powder
- •Extra Strength Headache, Caseys 4good
- •Midol Complete, Travel Basix
- •Excedrin Migraine, CVP Health
- •DRX Choice Tension Headache
- •Walgreens Pain Relief Powder
- •Sedal3X
- •Migrafein Forte
- •GenCare Headache Relief
- •basic care headache relief
- •Caffeine and Sodium Benzoate
- •Earthmed Uplift Chewable Watermelon
- •Signature Care Migraine Relief
- •good sense headache relief
- •Equaline migraine formula
- •AeroTab Pain Reliever
- •Orphengesic Forte
- •Caffeine 1508
- •Bayer Back and Body Extra Strength
- •Bayer Rapid Relief Body Pain
- •Headache, Circle K
- •Handy Solutions Headache Pain Relief
- •Menstrual Pain Relief
- •Extra Strength Headache Relief geltabs
- •Butal/APAP/Caffeine
- •New Hanbang Col Cap
- •Blowfish
- •Earthmed Uplift Chewable Strawberry
- •Syncol Max
- •Nuvicare Headache Relief
- •Migergot
- •pain relief back and body Extra Strength
- •Sedalmex Forte
- •Medi First Pain Ache
- •Comfort-Time
- •Diurex Ultra
- •Arthriten Inflammatory Pain Formula
- •Extra Pain Relief Acetaminophen, Aspirin (Nsaid) and Caffeine
- •Family Wellness Pain Relief Powder
- •Food Additives
- •DoloDent Toothache For adults
- •Norgesic
- •BC MAX
- •NoDoz Alertness Aid
- •Attend
- •Excedrin Migraine Geltabs
- •FLO PMS Complete
- •GUNA Sleep Support
- •Extra Strength PAIN Relief
- •Care One migraine relief
- •Vanquish Extra Strength
- •Diurex Ultimate
- •Extraprin
- •Texaclear PAIN Reliever
- •Bayer Headache
- •Aspirina Cafeina
- •Neo-Lubrina Fuerte
- •Mejoral
- •Agrifen
- •Menstrual Complete Pain Relief
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Industrial Uses
- •Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
Vendor Pricing
$0.06/gAK Scientific Specialized
CountryUnited States
Pack$61.00 / 1 kg
Purity98%
Vendors18 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
17 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Sigma-Aldrich (Rush Stock) | Germany | $0.06 | 25 kg | 99% |
| Sigma-Aldrich | Germany | $0.06 | 25 kg | 99% |
| AK Scientific, Inc. | United States | $0.08 | 1 kg | 99% |
| ALFA AESAR | Germany | $0.15 | 1 kg | 99% |
| Combi-Blocks, Inc. | United States | $0.25 | 1 kg | 98% |
| AstaTech, Inc | United States | $2.24 | 25 g | 99% |
| Cayman Europe | Estonia | $12.14 | 5 g | 98% |
| CliniSciences GmbH | Switzerland | $32.25 | 1 g | 99% |
| Interbioscreen | Hong Kong | $68.00 | 10 g | 95% |
| Labotest KG | Germany | $217.80 | 5000 mg | 90% |
| ChemFaces | China | $1500.00 | 20 mg | 98% |
| Otava, Ltd. | Ukraine | $2724.00 | 50 mg | 95% |
| Life Chemicals Inc. | Ukraine → Canada | $4650.00 | 100 mg | 90% |
| Asinex | Netherlands | $6461.40 | 100 mg | 90% |
| ChemBridge Corporation | Kazakhstan | $18000.00 | 5 mg | 90% |
| ChemDiv, Inc. | United States | $69000.00 | 1 mg | 90% |
| AnalytiCon Discovery - a Division of BRAIN Biotech AG | Germany | $73652.70 | 100 mg | 85% |
Chemical Identity
CAS58-08-2
PubChem CID2519
DTXSIDDTXSID0020232
FormulaC8H10N4O2
Mol. Weight194.19 g/mol
SMILESCN1C=NC2=C1C(=O)N(C(=O)N2C)C
Data Sources
- EPA CompTox (DSSTox) · DTXSID0020232Retrieved 2026-04-06
- PubChem · compound 2519Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Caffeine (CAS 58-08-2) https://chemicalindependence.com/chemical/58-08-2/ EPA CompTox (DSSTox): DTXSID0020232. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232 PubChem: 2519. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/2519 EPA Chemical Data Reporting: 58-08-2. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 58-08-2. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293930 for CAS 58-08-2. Reporting year: 2024. https://usatrade.census.gov/