leucovorin

Drug ingredient

CAS 58-05-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$295M

Top sourceChina 56%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293629 · basket

These shares come from HS customs code 293629, which covers 17 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 56%ChinaCH 12%SwitzerlandIN 12%IndiaIT 11%ItalyJP 2%Japan

Spain
Netherlands
Czech Republic
Israel
Guyana
Norway
Australia
Taiwan
Ivory Coast
Honduras
South Korea
Austria
Colombia
Brazil
Mexico
Belgium
South Africa
Turkey
Hong Kong
Chile
Slovenia
Ecuador
Sweden
Vietnam

2 FDA-registered drug labelers

Jaymac Pharmaceuticals

Jaymac Pharmaceuticals, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•EnBrace HR
•PaxLyte

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$50.50/gAngene Chemical

CountryChina (registered: Hong Kong)

Pack$505.00 / 10 g

Purity98%

Vendors20 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

19 more vendors

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$50.50	10 g	98%
Combi-Blocks, Inc.	United States	$106.00	5 g	95%
Ambeed, Inc.	United States	$119.40	5 g	98%
A2B Chem LLC	United States	$122.00	1 g	99.76%
AA BLOCKS	United States	$136.00	1 g	98%
Molnova	China	$152.00	500 mg	99%
BLD Pharmatech Co., Limited	United States	$171.00	1 g	98%
BLD Pharmatech GmbH	Germany	$171.00	1 g	98%
BLD Pharmatech Ltd.	China	$171.00	1 g	98%
AstaTech, Inc	United States	$195.80	5 g	95%
TargetMol Chemicals	China → United States	$478.00	500 mg	99.76%
MedKoo Biosciences, Inc	United States	$850.00	1 g	98%
ChemNorm	China	$1140.00	100 mg	98%
Apexbio Technology LLC	United States	$2040.00	50 mg	98%
Angene	China → Hong Kong	$4266.67	30 mg	98%
AK Scientific, Inc.	United States	$4400.00	100 mg	98%
MedChemExpress MCE	Sweden	$5505.50	100 mg	99.98%
Angene International Limited	United States	$7110.00	100 mg	98%
TimTec, LLC (back-ordered)	United States	$32000.00	15 mg	94%

Chemical Identity

CAS58-05-9

PubChem CID135403648

DTXSIDDTXSID0048216

FormulaC20H23N7O7

Mol. Weight473.4 g/mol

SMILESC1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Data Sources

PubChem · compound 135403648Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

leucovorin (CAS 58-05-9) https://chemicalindependence.com/chemical/58-05-9/ PubChem: 135403648. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135403648 FDA National Drug Code directory: CAS 58-05-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293629 for CAS 58-05-9. Reporting year: 2024. https://usatrade.census.gov/