L-Ascorbic acid calcium salt (2:1)

Drug ingredient

CAS 5743-27-1

EPA’s 2019 records show zero U.S. production for this drug ingredient.

Molecular structure of 5743-27-1 — 1 Ca²⁺

US productionZero

Import value, 2024$190M

Top sourceChina 73%

EPA lists this chemical for 2019 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293627 · narrow

EPA reports by year

2019: US production Zero · Imports Zero

These shares come from HS customs code 293627, which covers 6 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 73%ChinaGB 20%United KingdomIN 2%IndiaDE 1%GermanyKR 1%South Korea

Japan
Canada
Israel
Switzerland
Taiwan
Poland
Hong Kong
Denmark
Australia
Slovakia
Ukraine
Spain
Mexico
Belgium
Latvia
Italy
Ecuador
Georgia
Malaysia

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Colonial Group

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Nestabs ONE
•Se-Natal 19 Chewable

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS5743-27-1

PubChem CID54740489

DTXSIDDTXSID40110036

FormulaC12H14CaO12

Mol. Weight390.31 g/mol

SMILESC(C(C1C(=C(C(=O)O1)[O-])O)O)O.C(C(C1C(=C(C(=O)O1)[O-])O)O)O.[Ca+2]

Data Sources

EPA CompTox (DSSTox) · DTXSID40110036Retrieved 2026-04-06
PubChem · compound 54740489Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

L-Ascorbic acid calcium salt (2:1) (CAS 5743-27-1) https://chemicalindependence.com/chemical/5743-27-1/ EPA CompTox (DSSTox): DTXSID40110036. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID40110036 PubChem: 54740489. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/54740489 EPA Chemical Data Reporting: 5743-27-1. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293627 for CAS 5743-27-1. Reporting year: 2024. https://usatrade.census.gov/