Progesterone

Drug ingredient

CAS 57-83-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 57-83-0
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
78 FDA-registered drug labelers
A-S Medication Solutions
Acertis Pharmaceuticals, LLC
Actavis Pharma, Inc.
Allergan, Inc.
Amneal Pharmaceuticals LLC
Apex Energetics Inc.
Asclemed USA, Inc.
Aspen Oss B.V.
Aurobindo Pharma Limited
AvKARE
AX Pharmaceutical Corp
Bayer de Mexico, S.A. de C.V.
BioActive Nutritional, Inc.
BioActive Nutritionals, Inc.
Bionpharma Inc.
BLA Enterprises, LLC
Brichem Sciences Private Limited
Bryant Ranch Prepack
Carolinas Weight Loss Institute
Catalent Pharma Solutions LLC
Chemo Biosynthesis s.r.l.
Cutyx Research LLP
DARMERICA, LLC
Deseret Biologicals, Inc.
Direct Rx
DMD Clinical Naturopathy
Dr. Donna Restivo DC
Dr. Reddy's Laboratories Inc.
Elanco US Inc.
Energique, Inc.
Eugia US LLC
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
Fagron Inc
Ferring Pharmaceuticals Inc.
Fresenius Kabi USA, LLC
Galenova Inc
Golden State Medical Supply, Inc.
Guna spa
Hikma Pharmaceuticals USA Inc
HORSTER BIOTEK PVT LTD.
Hubei Gedian Humanwell Pharmaceutical Co.,Ltd
IHA Distribution, LLC
Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd.
Jiashen International Trade Limited
Kalchem International inc
La Chandra Pharmalab Private Limited
LETCO MEDICAL, LLC
Mayne Pharma
Mayne Pharma LLC
MEDISCA Inc.
Newton Laboratories, Inc.
Northstar Rx LLC
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
NURAY CHEMICALS PRIVATE LIMITED
Nutritional Specialties, Inc.
Patheon Softgels Inc.
Pharma Source Direct, Inc.
Pharmacia and Upjohn Company LLC
Preferred Pharmaceuticals Inc.
Pro Weight Loss Inc.
ProBLEN
Professional Complementary Health Formulas
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
REMEDYREPACK INC.
SCH Global Services Private Limited
SHYNE BRANDS
SHYNE BRANDS/BIOLabs PRO
Spectrum Laboratory Products, Inc.
STHREE CHEMICALS PRIVATE LIMITED
Symbiotec Pharmalab Limited
White Manufacturing Inc. BDA Micro-West
Wise Essentials LLC
Xenex Laboratories Inc
XIROMED, LLC
Zhejiang Shenzhou Pharmaceutical Co., Ltd
zhejiang xianju pharmaceutical co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 46 drug and cosmetic product listings (FDA).

  • •Progesterone
  • •Balance Plus Cream
  • •Weight Loss Support Plus Female Balance
  • •EstroPRO Homeopathic Organotherapy
  • •DHEA Forte
  • •Female Balance
  • •Strength F
  • •Progesterone vaginal insert
FDA Shortage Status
No Shortage
Shortage History
  • to be discontinued

    Progesterone Vaginal Gel

    Shortage listed since March 27, 2026

See all current drug shortages

Vendor Pricing

$2.57/gFluorochem UK
CountryUnited Kingdom
Pack$12.87 / 5 g
Purity98%
Vendors6 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS57-83-0
PubChem CID5994
DTXSIDDTXSID3022370
FormulaC21H30O2
Mol. Weight314.5 g/mol
SMILESCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Data Sources

Brief citations

Progesterone (CAS 57-83-0) https://chemicalindependence.com/chemical/57-83-0/ PubChem: 5994. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5994 EPA TSCA Inventory: CAS 57-83-0. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 57-83-0. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293723 for CAS 57-83-0. Reporting year: 2024. https://usatrade.census.gov/