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physostigmine salicylate

Drug ingredient

CAS 57-64-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 57-64-7
US productionNot reported
Import value, 2024$171M
Top sourceSwitzerland 40%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293979 · basket

These shares come from HS customs code 293979, which covers 60 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CH 40%SwitzerlandCN 18%ChinaIT 14%ItalyDE 13%GermanyIN 10%India
3 FDA-registered drug labelers
HF Acquisition Co LLC, DBA HealthFirst
Osauhing TBD Pharmatech
Provepharm Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

  • •Anticholium
  • •Physostigmine Salicylate
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS57-64-7
PubChem CID657348
DTXSIDDTXSID80883232
FormulaC22H27N3O5
Mol. Weight413.5 g/mol
SMILESCC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.C1=CC=C(C(=C1)C(=O)O)O

Data Sources

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Brief citations

physostigmine salicylate (CAS 57-64-7) https://chemicalindependence.com/chemical/57-64-7/ PubChem: 657348. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/657348 EPA TSCA Inventory: CAS 57-64-7. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293979 for CAS 57-64-7. Reporting year: 2024. https://usatrade.census.gov/