Flag of the United StatesAmerican Chemical Independence

ethinylestriol

Drug ingredient

CAS 57-63-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 57-63-6
US productionNot reported
Import value, 2024$76M
Top sourceSpain 35%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary
1 FDA-registered drug labeler
zhejiang xianju pharmaceutical co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 28 drug and cosmetic product listings (FDA).

  • •Etonogestrel and Ethinyl Estradiol Vaginal
  • •Zafemy
  • •Levonorgestrel and Ethinyl Estradiol
  • •EnilloRing
  • •norelgestromin and ethinyl estradiol
  • •Junel 21 Day
  • •Nuvaring
  • •Fyavolv
Show all 28
  • •Norethindrone Acetate AND Ethinyl Estradiol
  • •Jinteli
  • •Norelgestromin and Ethinly Estradiol
  • •Luizza 1/20
  • •Junel FE
  • •Loestrin 21 Day
  • •Etonogestrel/Ethinyl Estradiol
  • •Hailey 1.5/30
  • •Aurovela 1/20
  • •Dolishale
  • •Xulane
  • •Amethyst
  • •Etonogestrel and Ethinyl Estradiol
  • •Nortrel 21 Day
  • •Luizza 1.5/30
  • •Aurovela 1.5/30
  • •Twirla
  • •Etonogestrel and Ethinyl Estradiol Vaginal Ring
  • •EluRyng
  • •Annovera
FDA Shortage Status
No Shortage

Chemical Identity

CAS57-63-6
PubChem CID11723045
DTXSIDDTXSID5020576
FormulaC20H24O3
Mol. Weight312.4 g/mol
SMILESCC12CCC3C(C1CC(C2(C#C)O)O)CCC4=C3C=CC(=C4)O

Data Sources

← Back to Dashboard← Back to Health

Brief citations

ethinylestriol (CAS 57-63-6) https://chemicalindependence.com/chemical/57-63-6/ PubChem: 11723045. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/11723045 EPA TSCA Inventory: CAS 57-63-6. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 57-63-6. Retrieved 2026-06-13. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293723 for CAS 57-63-6. Reporting year: 2024. https://usatrade.census.gov/