Morphine

Drug ingredientActive Shortage

CAS 57-27-2

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$103M

Top sourceAustralia 31%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293911 · basket

These shares come from HS customs code 293911, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

AU 31%AustraliaGB 27%United KingdomCZ 19%Czech RepublicDE 14%GermanyES 5%Spain

Taiwan
New Zealand

4 FDA-registered drug labelers

ANI Pharmaceuticals, Inc.

Bryant Ranch Prepack

Edenbridge Pharmaceuticals, LLC

Purisys LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Opium Tincture Deodorized

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Morphine Sulfate Injection
Shortage listed since October 31, 2017
Manufacturer reports: 2 unavailable, 1 limited, 3 available
to be discontinued
Morphine Sulfate Tablet
Shortage listed since December 22, 2025

See all current drug shortages

Chemical Identity

CAS57-27-2

PubChem CID5288826

DTXSIDDTXSID9023336

FormulaC17H19NO3

Mol. Weight285.34 g/mol

SMILESCN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O

Data Sources

PubChem · compound 5288826Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Morphine (CAS 57-27-2) https://chemicalindependence.com/chemical/57-27-2/ PubChem: 5288826. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5288826 FDA National Drug Code directory: CAS 57-27-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 57-27-2. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293911 for CAS 57-27-2. Reporting year: 2024. https://usatrade.census.gov/