3-Methyl-2-butanone

CAS 563-80-4

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$39M

Top sourceChina 33%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291419 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291419, which covers 131 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 33%ChinaDE 29%GermanyIN 26%IndiaGB 3%United KingdomJP 2%Japan

Netherlands
Italy
Brazil
South Africa
Turkey
Moldova
Canada
Armenia
Slovakia
Finland
Hong Kong
Mexico
Ukraine

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Eastman Chemical

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.24/gAA BLOCKS

CountryUnited States

Pack$120.00 / 500 g

Purity99%

Vendors7 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

6 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$0.24	500 g	99%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
AstaTech, Inc	United States	$0.80	500 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS563-80-4

PubChem CID11251

DTXSIDDTXSID0022062

FormulaC5H10O

Mol. Weight86.13 g/mol

SMILESCC(C)C(=O)C

Data Sources

EPA CompTox (DSSTox) · DTXSID0022062Retrieved 2026-04-06
PubChem · compound 11251Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

3-Methyl-2-butanone (CAS 563-80-4) https://chemicalindependence.com/chemical/563-80-4/ EPA CompTox (DSSTox): DTXSID0022062. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID0022062 PubChem: 11251. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/11251 EPA Chemical Data Reporting: 563-80-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 563-80-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291419 for CAS 563-80-4. Reporting year: 2024. https://usatrade.census.gov/