Doxylamine succinate
Drug ingredientCAS 562-10-7
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$1.3B
Top sourceChina 32%
This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293339 · basket
These shares come from HS customs code 293339, which covers 397 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
CN 32%ChinaIN 15%IndiaDE 10%GermanyBE 9%BelgiumCH 8%Switzerland
- Taiwan
- Ukraine
- Sweden
- Argentina
- Canada
- Finland
- Malta
- Israel
- Netherlands
- Denmark
- United Arab Emirates
- Mexico
- Brunei
- Slovakia
- Australia
- South Africa
- Poland
- Latvia
- Lithuania
- Estonia
- Slovenia
- Czech Republic
- Croatia
- Hong Kong
132 FDA-registered drug labelers
Actavis Pharma, Inc.
Advanced Rx LLC
Allegiant Health
AMAZON.COM SERVICES LLC
American Sales Company
Amerisource Bergen
Analog Pharma
APL HEALTHCARE LIMITED
AptaPharma Inc.
ARMY AND AIR FORCE EXCHANGE SERVICE
Aurohealth LLC
Bayer HealthCare LLC.
Belmora LLC
Best Choice (Valu Merchandisers Company)
BETTER LIVING BRANDS LLC.
BI-MART
Big Lots Stores, Inc.
Bionpharma Inc.,
Bioventure Healthcare - FZE
BJWC
Bryant Ranch Prepack
Cardinal Health 110, LLC. DBA Leader
CARDINAL HEALTH 110, LLC. DBA LEADER 70000
Care One (Retail Business Services, LLC.)
Catalent Ontario Limited
Chain Drug Consortium, LLC
Chain Drug Marketing Association, Inc.
Chattem, Inc.
COSTCO WHOLESALE CORPORATION
Cutyx Research LLP
CVS
CVS HEALTH CORP
CVS PHARMACY
CVS PHARMACY, INC
CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED
DeMoulas Market Basket
Discount Drug Mart
Dolgencorp Inc
Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)
Dolgencorp, LLC
Duchesnay USA, Inc.
EFFICIENT LABORATORIES INC
ELYSIUM PHARMACEUTICALS LIMITED
Elysium Pharmaceuticals Ltd
Endo USA, Inc.
EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC)
FAMILY DOLLAR
Family Dollar (FAMILY WELLNESS)
FAMILY DOLLAR SERVICES INC
Family Dollar Stores, Inc
FSA Store Inc. (Caring Mills)
Genomma Lab USA
Gobrands, Inc. (Goodnow)
Grimann, S.A. de C.V.
Grocery Outlet
H E B
Haleon US Holdings LLC
Harris Teeter, LLC
Health Pharma USA LLC
HealthLife of USA
Honour Lab Limited
Humanwell PuraCap Pharmaceutical (Wuhan) Co., Ltd.
Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.
HY-GRO CHEMICALS PHARMTEK PRIVATE LIMITED
HyVee Inc
Kenvue Brands LLC
Kramer Laboratories
KROGER
Kroger Company
L Perrigo Company
L.N.K. International, Inc.
Lidl US LLC
Lil' Drug Store Products, Inc
Major Pharmaceuticals
Malladi Drugs & Pharmaceuticals Limited
MEDWISE LIFESCIENCES INC.
MEIJER DISTRIBUTION INC
Meijer, Inc.
Mylan Pharmaceuticals Inc.
NUVICARE LLC
OPMX LLC
P & L Development, LLC
Patheon Softgels Inc.
Pharmadel LLC
Pioneer Life Sciences, LLC
Poly Pharmaceuticals, Inc.
Procter & Gamble Manufacturing Company
Prodose, Inc.
Professional Compounding Centers of America dba PCCA
Publix Super Markets Inc
PuraCap Pharmaceutical LLC
QUALITY CHOICE (Chain Drug Marketing Association)
R.L.Fine Chem Private Limited
RARITAN PHARMACEUTICALS INC
RB Health (US) LLC
Retail Business Services, LLC
RITE AID
Rite Aid Corporation
Rnv LLC
Safeway
Safeway, Inc.
SALADO SALES INC.
Sambrosa Care, Inc.
Shenzhen Oriental Pharmaceutical Co. Ltd
Shield Pharmaceuticals Corp
Sigma-Aldrich Ireland Ltd.
SOFTGEL HEALTHCARE PRIVATE LIMITED
Softgel Healthcare Pvt Ltd
Spectrum Laboratory Products, Inc.
Sportpharm LLC
Strategic Sourcing Services LLC
Strive Pharmaceuticals Inc.
TARGET CORP
TARGET CORPORATION
The Kroger Co.
The Kroger Company
The Procter & Gamble Manufacturing Company
TopCo Associates, LLC
Union Quimico Farmaceutica SA (UQUIFA)-Sant Celoni
United Natural Foods, Inc. dba UNFI
Velocity Pharma
VESPYR BRANDS, INC.
VIVUNT PHARMA LLC
Wal-Mart Stores Inc
WALGREEN CO.
WALGREEN COMPANY
WALGREENS
WALGREENS CO
WALMART INC.
WALMART INC. (see also Equate)
WinCo Foods, LLC
YYBA CORP
Why It Matters
Sectors
Health
Downstream Uses
Appears in 235 drug and cosmetic product listings (FDA).
- •Contac COLD and FLU
- •Nighttime Cold and Flu
- •NiteTime Severe Cold and Flu Relief Softgels
- •equate Maximum Strength Nighttime Severe Cold and Flu Softgels
- •Quality Choice NightTime Severe Cold and Flu
- •Vicks NyQuil-D COLD and Sinus plus Severe Congestion
- •Nuvicare NightTime Cold and Flu Softgel
- •Onessip Adult Nighttime Severe COLD AND FLU
Show all 235
- •Nighttime Cold and Flu Liquid
- •sleep aid
- •Nighttime Cold and Flu Relief
- •Night Time Cough
- •Kroger Nighttime Cold and Flu Softgel
- •good sense sleep aid ultra
- •Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride
- •Acetaminophen, Dextromethorphan Hydrobromide and Doxylamine Succinate
- •TopCare Sleep Aid
- •Vicks NyQuil Severe Cold and Flu
- •NyQuil Severe plus Vicks VapoCool Cold and Flu
- •good neighbor pharmacy night time
- •Nighttime Sleep Aid
- •Night-TIME Multi-Symptom COLD/FLU Cherry
- •Night-Time Cough Relief
- •Nighttime Cold/Flu Relief
- •Diclegis
- •Sanatos Nighttime Multi Symptoms
- •Nitetime
- •Severe Nighttime
- •Robitussin Nighttime Cough DM Soft Chews
- •Cough Relief Nighttime
- •24-7 Life BY 7-Eleven Nighttime Cold and Flu
- •NightTime Cold and Flu Multi Symptom
- •Cold and Flu
- •Childrens HoneyWorks Plus Nighttime Cough Syrup
- •Nighttime COLD AND FLU Maximum Strength
- •Night Time Cold and Flu original
- •Vicks NyQuil Ultra Concentrated COLD and FLU
- •Vicks NyQuil HIGH Blood Pressure Cold and Flu
- •Tussin DM
- •Night Time Cold and Flu Relief Multi Symptom
- •Leader Nighttime Cold and Flu
- •basic care nighttime severe cold and flu
- •Mucinex Childrens Mighty Chews Cough Nighttime
- •Topcare NiteTime Cold and Flu Relief
- •TopCare Nite Time Severe Cold and Flu
- •Nite-Time COLD/FLU Medicine Cherry
- •equate nighttime cold and flu
- •Multi-Symptom Nighttime Cold and Flu Relief
- •Vicks NyQuil Allergy
- •Vicks NyQuil VapoCOOL COLD and FLU
- •good sense night time
- •NightTime Severe Cold and Flu
- •Nitetime Cold and Flu
- •equate vapor ice cold and flu
- •NiteTime Cold/Flu, Multi-Symptom Relief
- •Tukol Honey Nighttime Cold and Flu
- •Cold and Flu Nighttime Severe
- •Night Time Severe Cold and Flu Relief
- •dg health night time cold and flu relief
- •nighttime
- •Nite-Time COLD/FLU Original
- •Doxylamine Succinate and Pyridoxine Hydrochloride
- •Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels
- •Cold and Flu Nighttime
- •Circle K Nighttime Cold and Flu
- •Nighttime Severe, Cold and Flu, 24-7 Life by 7-Eleven
- •Walgreens Nighttime Allergy Relief
- •Vicks NyQuil FOR People WITH Diabetes COLD and FLU
- •Right Remedies Nighttime Severe COLD AND FLU softgel
- •Sleep AID 25mg
- •XL-3 Xtreme
- •meijer Nighttime Cold and Flu Softgel
- •Quality Choice Maximum Strength Nighttime Cold and Flu
- •Vicks NyQuil Elderberry COLD and FLU
- •Vicks NyQuil Intense FLU
- •Nightime COLD AND FLU
- •Multi-Symptom COLD AND FLU Relief Nighttime
- •Signature Care Nighttime Severe Cold and Flu Relief
- •Good Sense Severe NightTime Cold and Flu
- •Nocto Sleep Aid
- •Acetaminophen, Dextromethorphan HBr and Doxylamine Succinate
- •Severe Cold and Flu Nighttime Honey
- •Tylenol Cold plus Flu plus Cough Night
- •Tussin DM Nighttime
- •dg health sleep aid
- •Nite-TimeCOLD/FLU Cherry COLD/FLU Cherry
- •Alka-Seltzer Plus Severe Cold Night PowerFast Fizz
- •Alka-Seltzer Plus Cold Night
- •Alka-Seltzer Plus Maximum Strength Night Cold and Flu
- •Cold and Flu Nighttime Severe, 24-7 Life
- •ZzzQuil Ultra, Lil Drug Store
- •HoneyWorks Plus Adult Nighttime Cough Syrup
- •Walgreens Nighttime Kids Honey Cold Cough Congestion
- •Vicks ZzzQuil Ultra
- •Vicks NyQuil Kids Honey Cold Cough Congestion
- •Pentrexcilina Night Time
- •tabcin Night
- •basic care nighttime cold and flu
- •Amazon Maximim Strength Adult Nighttime Cough DM
- •topcare nite time cold and flu
- •Nighttime Cold and Flu Max Softgels
- •Revasol Nighttime COLD AND FLU
- •Nighttime Cherry COLD AND FLU
- •Severe Sinus Congestion Allergy and Cough Formula
- •CVS Dex-Dox Kids Nighttime Cough Suppressant
- •Original Night-Time Multi-Symptom COLD/FLU Relief
- •Night-Time Multi-Symptom Cold/Flu Relief
- •Family Dollar Nighttime Cold and Flu Relief Original Flavor
- •Sanatos Nighttime
- •DG Health COLD FLU Relief
- •Rompe Pecho NT NT
- •Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime
- •Cold and Flu Relief Multi Symptom Nighttime
- •Nite Time Cold and Flu Relief
- •Nighttime Cold and Flu Multi Symptom Relief
- •Vicks NyQuil Cold and Flu Nighttime Relief
- •up and up nighttime cold and flu
- •Good sense sleep aid
- •equaline nighttime cold and flu relief
- •Unisom SleepTabs
- •CareOne Nighttime Severe Cold and Flu
- •Night Time Cold and Flu ReadyInCase
- •Extra Strength Tylenol Severe Cough Plus Sore Throat Night
- •CVS Nighttime Cold and Flu Relief
- •Family Dollar Nighttime Cold and Flu Relief
- •Severe cold and flu Nighttime
- •nitetime severe
- •Nighttime Severe
- •Robitussin Maximum Strength Nighttime Cough DM
- •Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels
- •severe cold and flu
- •Walgreens Adult Nighttime Wal Tussin DM Max Maximum Strength
- •NyQuil VapoCOOL Severe COLD and FLU plus Congestion
- •ultra sleep aid
- •Nighttime COLD AND FLU Cherry
- •Cold and Flu Night
- •Cold and Flu plus Congestion Nighttime
- •AXIM Night Time - Liquid
- •Vicks NyQuil Kids COLD and Cough plus Fever
- •Vicks NyQuil Cold and Flu
- •up and up nighttime sleep aid
- •severe cold and flu relief
- •Kroger Nighttime Cold and Flu Relief
- •Nightime
- •CareOne Night TIme Cold and Flu
- •good neighbor pharmacy night time cold and flu
- •Tussin DM Max Nighttime
- •sound body nighttime sleep aid
- •Nighttime Cough DM
- •Night Cold Flu Cough and Allergy
- •Severe Nighttime Cold and Flu Relief
- •Cold and Flu Relief Nighttime
- •dg health tussin
- •Nighttime Sleep Aid, 24-7 Life by 7-Eleven
- •Nighttime Relief, Cold and Flu, 24-7 Life by 7-Eleven
- •NyQuil Cold and Flu w/VapoCOOL, 4ct, CVP Health
- •berkley and jensen sleep aid
- •foster and thrive nighttime severe cold and flu relief
- •Mucinex Childrens Mighty Chews Night Time Cold and Flu
- •Nighttime Cold and Flu Liquid Cherry
- •Coricidin HBP Nighttime Multi-Symptom Cold
- •Nighttime Severe Honey Cold and Flu
- •CareOne Nighttime Sleep Aid
- •tussin dm nighttime max
- •Poly Hist Forte
- •Ultra Concentrated Nighttime COLD AND FLU
- •NightTime Sinus
- •Night-TIME Multi-Symptom COLD/FLU Original
- •Night Time Multi-Symptom Cold and Flu Relief
- •Safetussin PM Nighttime Cough relief
- •Antigrip Nighttime
- •DG Health Cold and Flu Relief
- •Robitussin Honey Maximum Strength Nighttime Cough DM
- •Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough
- •NyQuil Cold and Flu w/VapoCOOL, 4ct, Travel Basix
- •NyQuil Severe Plus VapoCOOL Cold and Flu, Travel Basix
- •ZzzQuil Ultra, Travel Basix
- •Maximum Strength Nighttime Severe Cold and Flu
- •Nighttime Ultra Concentrated Cold and Flu
- •Walgreen High Blood Pressure Nighttime Cold and Flu
- •Vicks NyQuil Severe Honey Cold and Flu
- •Ampigrin Ultra Forte Night
- •foster and thrive nighttime cold and flu relief
- •Nite-Time COLD/FLU Medicine
- •Meijer Nitetime Cold and Flu Relief
- •Vicks NyQuil Kids Allergy
- •XL-3 Night Time
- •equaline nighttime severe cold and flu
- •meijer Maximum Strength Nighttime Cough DM
- •cold flu
- •ASP Nighttime Max
- •Cold and Flu Relief
- •DG Health Cold and Flu Severe
- •Alka-Seltzer Plus Night Severe Cold and Flu
- •Vicks NyQuil Severe Honey Flavor COLD and FLU
- •Vicks NyQuil Cough DM plus Congestion
- •Nighttime COLD AND FLU Relief Softgels Multi-Symptom
- •Good Sense Severe NightTime
- •good sense night time cold and flu
- •topcare tussin dm max
- •Tylenol COLD PLUS FLU Multi-Symptom GELS Night
- •Cold and Flu Nighttime Relief
- •CVS NightTime Cold
- •NightTime Sinus Relief
- •Maximum Strenth Night COLD AND FLU Formula
- •Sanatos Multi Symptoms Nighttime
- •Sanatos Nighttime Relief
- •dg health cold and flu
- •Rompe Pecho Nighttime
- •NyQuil Severe Plus VapoCOOL Cold and Flu, CVP Health
- •Nighttime Cold and Flu Lil Drug Store Products
- •NyQuil Severe Plus VapoCOOL Cold and Flu
- •sleep aid ultra
- •AXIV NightTime
- •AXIV Night Time - Liquid
- •Nighttime Cold and Flu Mini Softgels
- •all nite
- •tussin nighttime cough
- •Nite time Severe Cold and Flu Maximum Strength
- •careone tussin dm
- •Cough DM Nighttime
- •Bonjesta
- •Sambrosa Night
- •Childrens Robitussin Honey Nighttime Cough DM
- •Alka-Seltzer Plus Severe Cold Powerfast Fizz Night
- •NyQuil Cold and Flu w/VapoCOOL, 4ct, Lil Drug Store
- •DRX Choice Nighttime COLD and FLU Relief
- •Walgreen NightTime Cold and Flu relief
- •Vicks NyQuil VapoCOOL Severe COLD and FLU plus Congestion
- •Severe Nighttime COLD AND FLU
- •Walgreens NightTime Cold and Flu
- •Nitecin
- •Viro Flu PM Relief
- •Nighttime HBP Cold and Flu Relief
- •Basic Care Sleep Aid
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No Shortage
Shortage History
Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.
- to be discontinued
Doxylamine Succinate and Pyridoxine Hydrochloride Tablet, Delayed Release
Shortage listed since January 12, 2026
Vendor Pricing
$2.76/gA2B Chem LLC
CountryUnited States
Pack$69.00 / 25 g
Purity99%
Vendors23 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
22 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| AA BLOCKS | United States | $2.92 | 25 g | 99% |
| Aaron Chemicals LLC | Hong Kong | $3.84 | 50 g | 99% |
| Angene Chemical | China → Hong Kong | $3.88 | 50 g | 99% |
| AstaTech, Inc | United States | $5.88 | 25 g | 95% |
| Combi-Blocks, Inc. | United States | $6.00 | 25 g | 98% |
| AK Scientific Specialized | United States | $6.98 | 50 g | 95% |
| AK Scientific, Inc. | United States | $8.72 | 50 g | 98% |
| Fulfilled by Molport | Latvia | $10.00 | 1 g | 99% |
| Life Chemicals Inc. | Ukraine → Canada | $12.00 | 5 g | 95% |
| Sigma-Aldrich (Rush Stock) | Germany | $12.54 | 50 g | — |
| Sigma-Aldrich | Germany | $12.54 | 50 g | — |
| MedChemExpress MCE | Sweden | $39.45 | 5 g | 99.76% |
| TargetMol Chemicals | China → United States | $98.00 | 1 g | 99.99% |
| MedKoo Biosciences, Inc | United States | $110.00 | 5 g | 98% |
| TargetMol Chemicals US | United States | $176.00 | 500 mg | 99.99% |
| Molnova | China | $460.00 | 200 mg | 99% |
| TargetMol Chemicals EU | Austria | $610.00 | 100 mg | 99.99% |
| Apexbio Technology LLC | United States | $1000.00 | 50 mg | 98% |
| Angene International Limited | United States | $2720.00 | 100 mg | 98% |
| Otava, Ltd. (2 weeks) | Ukraine | $2724.00 | 50 mg | 90% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 99% |
| Key Organics Ltd. | United Kingdom | $6900.00 | 10 mg | 98% |
Chemical Identity
CAS562-10-7
PubChem CID11224
DTXSIDDTXSID7020552
FormulaC21H28N2O5
Mol. Weight388.5 g/mol
SMILESCC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O
Data Sources
- PubChem · compound 11224Retrieved 2026-04-07
- FDA National Drug Code directoryRetrieved 2026-04-25
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Doxylamine succinate (CAS 562-10-7) https://chemicalindependence.com/chemical/562-10-7/ PubChem: 11224. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/11224 FDA National Drug Code directory: CAS 562-10-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 562-10-7. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293339 for CAS 562-10-7. Reporting year: 2024. https://usatrade.census.gov/