histamine dihydrochloride
Drug ingredientCAS 56-92-8
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$114M
Top sourceChina 26%
This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293329 · basket
These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy
- Australia
- Brazil
- Czech Republic
- Ireland
- Sweden
- Ukraine
- Poland
- United Arab Emirates
- Hungary
- Israel
- Netherlands
- Canada
- Saudi Arabia
- Greece
- Belgium
- Austria
- Latvia
- Singapore
- Denmark
59 FDA-registered drug labelers
ALPHA NUTRITION, LLC
American Standard Nutraceuticals
Apex Energetics Inc.
Apotheca Company
BAKER'S BEST HEALTH PRODUCTS, INC.
Baker's Best Health Products, LLC
Be Well Medical dba Richard Clement Nutrition y Be Well Homeopathics
Beyond Derma, LLC
BioActive Nutritional
BioActive Nutritional, Inc.
Boiron
Church & Dwight Co., Inc.
CMI Therapy Solutions
CVS Health
Deseret Biologials, Inc.
Deseret Biologicals, Inc.
DNA Labs, Inc.
Dr. Donna Restivo DC
Dr. Mike's Vitamins, LLC
Eight and Company L.L.C
Energetix Corporation
Energique, Inc.
FUSION PAIN SOLUTIONS LLC
GMP Laboratories of America, Inc.
Green Pharmaceuticals Inc
Guna spa
Heilen
Homeocare Laboratories
Homeolab International (Canada) inc
Hyland's Inc.
IDEAZ, LLC
Integrative Healing Institute, LLC
King Bio Inc.
Laboratoires Boiron
Laboratorium Ofichem BV
Liddell Laboratories
Liddell Laboratories, Inc.
Mediapower, Inc. DBA Dr Newton's And Naturals
MediNatura Inc.
Natural Creations, Inc
NaturalCare
Nenningers Naturals, LLC
Net Remedies
Newton Laboratories, Inc.
Nutritional Specialties, Inc.
OHM PHARMA INC.
Pain & Stress Center Products
Professional Complementary Health Formulas
Ratis, LLC
SEVENE USA
Silver Star Brands
Sombra Cosmetics Inc.
Source Naturals, Inc.
Talbot's Pharmaceuticals Family Products, LLC
Theraplex Solutions
TRP Company
True Botanica, LLC
VIREO SYSTEMS, INC.
Walgreens Company
Why It Matters
Sectors
Health
Downstream Uses
Appears in 161 drug and cosmetic product listings (FDA).
- •Dr. Talbots Daily Allergy Relief
- •Alo Therapeutic Massage
- •Bakers Best Arthritis Pain Relief
- •Grass Mix
- •2nd Chance Mobility Pain Relief
- •GUNA HAY Fever Relief
- •Allergy Pollen
- •Neuro II
Show all 161
- •Itch Formula
- •Lung Distress
- •Pollen Distress
- •Histaminum hydrochloricum
- •Cold - Sinus
- •Rashes-Hives
- •Hay Fever
- •Allergies
- •Allergy Relief Indoor and Outdoor
- •AllergEase
- •SnoreStop Chewable Fast tabs 60
- •PMS Relief
- •Bread Cravings
- •Nightshade Mix 1011
- •Nut Mix 1012
- •Northeast Regional 1021
- •Pollinosis Combination 9261
- •Aller-Chord F
- •Real Relief
- •Grass Pollen
- •Histaminum hydrochloricum 30C - 3-Pack
- •Household Dust and Mold Mix
- •Poison Ivy and Oak Formula
- •Ropana Pain Relief Cream
- •Natural Eyes Allergy Eye Relief Fast Dissolving Tables
- •Allergy Rescue
- •Bio Cytotox Phase
- •Allergen II
- •Neurotransmitter Pro
- •Insect Bites
- •Histaminum 30C Allergy Relief
- •Sniffles
- •Pollen-Weeds
- •Cold - Cough
- •BronCare
- •911 Stress and Anxiousness
- •Snore Control
- •Mold Relief Formula
- •Caffeine Mix 1003
- •Northwest Regional 1019
- •Airborne 1025
- •A02 Gentle Drainage
- •B08 Mucous Membranes
- •OHM Allergy Animal Mix
- •OHM Allergy Mold Mix
- •Mold, Yeast and Dust
- •Allergy Care
- •Amino Active Topical Analgesic Cream
- •Tree Mix
- •Animal Mix
- •VACC HC
- •Dairy Allergen Mix
- •Vital Weight Loss XL
- •Airway Ease
- •Dust-Mold-Dander
- •Panic Ease
- •Influenza
- •Seasonal Allergy Formula
- •Allergycalm
- •Sombra Max
- •Pets 1001
- •Smoke Mix 1023
- •Histamine 1522
- •Sinus
- •Allergy Drops
- •Dr Talbots Infant Daily Allergy Relief
- •Histaminum Hydrochloricum 200ck
- •Pollen and Dander Liquescence
- •Zicam Allergy Relief
- •GUNA-Allergy T
- •GUNA-Rhino NOSE
- •Asthma Therapy
- •Enviro I
- •Histastat Pollen
- •Cold Hands - Feet
- •Flu Care
- •Diet Power
- •Snorestop
- •Southeast Regional 1024
- •Causticum Combination 9253
- •B20 Acute Rescue
- •S01 Allerdrain
- •S12 Airborne
- •CVS Arthritis Pain Relief
- •Outdoor Allergies
- •Bakers Best Arthritis Pain Relief with Hemp Seed
- •Triple Allergy Defense
- •Histamine 6X
- •Mold Antigens
- •Mast Cell Pro
- •Snore-Soothe
- •Sinus Relief
- •SnoreStop Extinguisher 120
- •B01 Acute Rescue
- •DR. Mikes Ponos Pain Relief Cream Roll-On
- •Bakers BEST Arthritis Pain Relief Cream with Hemp and Lavender
- •Glucosamine Cream Extra Strength
- •GUNA PAIN Management
- •Allergen I
- •Histaminum Hydrochloricum 30X
- •Panic Button
- •A-36
- •Snore Stop Extinguisher Throat
- •Clearlife Extra Strength
- •Biting Insect Mix 1002
- •Dairy Mix 1004
- •Poison Ivy/Oak 1013
- •Trees 2 1017
- •Vegetable Mix 1018
- •Opsin I 6014
- •Opsin II 6015
- •S02 Aller-Total
- •Phase 6 Drops
- •Tree Pollen
- •Allergy Escape
- •TerraFreeze Pain Relief
- •Histamine
- •Pest and Dustmite Formula
- •Multi-Phenolic
- •ALO Therapeutic Massage PAIN Relieving
- •Seasonal Allergy Relief
- •Cough - Airway
- •Hives-Rashes
- •A-35
- •ER 911
- •Allergy Liquescence 3031
- •OHM Sinus Nasal
- •Walgreens Arthritis Pain Relief Cream
- •Histamine Balancer
- •Grass and Weed Mix
- •Allermilk
- •First Aid mind and Body
- •D1 Organ Support
- •Flowers 1008
- •Trees 1 1016
- •Grain and Wheat
- •Heilen
- •Allergy Mix Las Vegas
- •GUNA-Allergy-PREV
- •GUNA Allergy
- •Histamine Phenolic
- •Food Additives
- •B03 Sinus Relief
- •B19 Acute Rescue
- •Pain Relieving Cream
- •Nasal
- •Detox I
- •Neuro Links
- •Southwest Regional 1020
- •B21 Acute Rescue
- •N03 Exchem
- •Allercetin
- •AllergiClear-M
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Chemical Identity
CAS56-92-8
PubChem CID5818
DTXSIDDTXSID1058767
FormulaC5H11Cl2N3
Mol. Weight184.06 g/mol
SMILESC1=C(NC=N1)CCN.Cl.Cl
Data Sources
- PubChem · compound 5818Retrieved 2026-04-07
- EPA TSCA InventoryRetrieved 2026-04-24
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
histamine dihydrochloride (CAS 56-92-8) https://chemicalindependence.com/chemical/56-92-8/ PubChem: 5818. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5818 EPA TSCA Inventory: CAS 56-92-8. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 56-92-8. Reporting year: 2024. https://usatrade.census.gov/