Ethanedioic acid, dimethyl ester

CAS 553-90-2

EPA’s 2019 records show zero U.S. production of this chemical.

US productionZero

Import value, 2024$11M

Top sourceSpain 45%

EPA lists this chemical for 2023 but publishes zero or no volume for both production and imports.

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291711 · basket

EPA reports by year

2023: US production Not published · Imports Not published
2019: US production Zero · Imports Zero

These shares come from HS customs code 291711, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

ES 45%SpainCN 25%ChinaIN 10%IndiaTW 6%TaiwanIT 6%Italy

Belgium
Switzerland
Japan

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Pht International

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.04/gA2B Chem LLC

CountryUnited States

Pack$22.00 / 500 g

Purity99%

Vendors14 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

13 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$0.05	500 g	99%
ALFA AESAR	Germany	$0.15	2.5 kg	99%
AK Scientific Specialized	United States	$0.16	500 g	98%
AK Scientific, Inc.	United States	$0.22	500 g	99%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
Sigma-Aldrich (Rush Stock)	Germany	$0.35	500 g	99%
Sigma-Aldrich	Germany	$0.35	500 g	99%
AstaTech, Inc	United States	$0.35	500 g	95%
Fluorochem UK	United Kingdom	$1.49	25 g	99%
Interbioscreen	Hong Kong	$10.00	10 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS553-90-2

PubChem CID11120

DTXSIDDTXSID9060287

FormulaC4H6O4

Mol. Weight118.09 g/mol

SMILESCOC(=O)C(=O)OC

Data Sources

EPA CompTox (DSSTox) · DTXSID9060287Retrieved 2026-04-06
PubChem · compound 11120Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ethanedioic acid, dimethyl ester (CAS 553-90-2) https://chemicalindependence.com/chemical/553-90-2/ EPA CompTox (DSSTox): DTXSID9060287. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9060287 PubChem: 11120. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/11120 EPA Chemical Data Reporting: 553-90-2. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 553-90-2. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291711 for CAS 553-90-2. Reporting year: 2024. https://usatrade.census.gov/