levothyroxine sodium

Drug ingredient

CAS 55-03-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 55-03-8
1 Na⁺
US productionNot reported
Import value, 2024$174M
Top sourceItaly 69%

EPA lists this chemical as inactive, meaning no company reported making, importing or processing it in the US from 2006 to 2016.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293790 · basket

These shares come from HS customs code 293790, which covers 10 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 69%ItalyCN 22%ChinaDE 3%GermanyIN 2%IndiaJP 2%Japan
57 FDA-registered drug labelers
A-S Medication Solutions
AbbVie Inc.
AbbVie Ireland NL B.V.
Accord Healthcare Inc.
Alvogen, Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
ASCLEMED USA INC.
Aurobindo Pharma Limited
Aurore Pharmaceuticals Private Limited
Azico Biophore India Private Limited
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
Coupler LLC
DIRECT RX
Excella GmbH & Co. KG
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
Fagron Inc
Fresenius Kabi USA, LLC
Hikma Pharmaceuticals USA Inc.
IBSA Pharma Inc.
Lannett Company, Inc
LETCO MEDICAL, LLC
LUPIN LIMITED
Lupin Pharmaceuticals, Inc.
Macleods Pharmaceuticals Limited
Major Pharmaceuticals
Medisca Inc.
MSN Laboratories Private Limited
Mylan Institutional Inc.
Mylan Pharmaceuticals Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
Neolpharma, Inc.
NorthStar RxLLC
Northwind Health Company, LLC
NuCar Pharmaceuticals,Inc.
NuCare Pharmaceuticals, Inc.
Oliva Therapeutics, LLC
PD-Rx Pharmaceuticals, Inc.
Peptido GmbH
Pfizer Laboratories Div Pfizer Inc
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America
Proficient Rx LP
Provell Pharmaceuticals, LLC
Redpharm drug
RedPharm Drug, Inc
REMEDYREPACK INC.
Sandoz GmbH
Spectrum Laboratory Products, Inc.
Teva Pharmaceuticals, Inc.
VALARY LAB PRIVATE LIMITED
Viatris Specialty LLC
XLCare Pharmaceuticals, Inc.
YARAL Pharma Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 10 drug and cosmetic product listings (FDA).

  • •Levothyroxine Sodium
  • •Tirosint
  • •Tirosint SOL
  • •Synthroid
  • •Levoxyl
  • •Unithroid
  • •LEVO-T
  • •Euthyrox
FDA Shortage Status
No Shortage
Shortage History
  • to be discontinued

    Levothyroxine Sodium Tablet

    Shortage listed since July 10, 2025

See all current drug shortages

Vendor Pricing

$7.10/gCombi-Blocks, Inc.
CountryUnited States
Pack$710.00 / 100 g
Purity95%
Vendors18 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS55-03-8
PubChem CID23666112
DTXSIDDTXSID90883228
FormulaC15H10I4NNaO4
Mol. Weight798.85 g/mol
SMILESC1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])N.[Na+]

Data Sources

Brief citations

levothyroxine sodium (CAS 55-03-8) https://chemicalindependence.com/chemical/55-03-8/ PubChem: 23666112. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/23666112 EPA TSCA Inventory: CAS 55-03-8. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA Drug Shortages: CAS 55-03-8. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293790 for CAS 55-03-8. Reporting year: 2024. https://usatrade.census.gov/