1,4-Dioxacyclohexadecane-5,16-dione

CAS 54982-83-1

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$286M

Top sourceChina 48%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293220 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 293220, which covers 151 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 48%ChinaIN 15%IndiaJP 7%JapanGB 7%United KingdomCH 7%Switzerland

Mexico
Austria
Indonesia
Czech Republic
Slovakia
Malaysia
Israel
Poland
Vietnam
Ukraine
South Africa
Singapore
Russia
Lithuania
Hungary
Belarus
Brazil
Australia

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Givaudan Fragrances

International Flavors And Fragrances

Why It Matters

Sectors

Consumer ProductsCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 2 sectors as 1 functional role.

•Fragrance in All Other Chemical Product and Preparation Manufacturing (98%)Processing—incorporation into formulation, mixture, or reaction product
•Fragrance in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS54982-83-1

PubChem CID41270

DTXSIDDTXSID1044568

FormulaC14H24O4

Mol. Weight256.34 g/mol

SMILESC1CCCCCC(=O)OCCOC(=O)CCCC1

Data Sources

EPA CompTox (DSSTox) · DTXSID1044568Retrieved 2026-04-06
PubChem · compound 41270Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1,4-Dioxacyclohexadecane-5,16-dione (CAS 54982-83-1) https://chemicalindependence.com/chemical/54982-83-1/ EPA CompTox (DSSTox): DTXSID1044568. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1044568 PubChem: 41270. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/41270 EPA Chemical Data Reporting: 54982-83-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 54982-83-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293220 for CAS 54982-83-1. Reporting year: 2024. https://usatrade.census.gov/